A high pretreatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin's lymphoma

被引:229
作者
Salven, P [1 ]
Teerenhovi, L [1 ]
Joensuu, H [1 ]
机构
[1] UNIV HELSINKI, CENT HOSP, DEPT ONCOL, FIN-00290 HELSINKI, FINLAND
关键词
D O I
10.1182/blood.V90.8.3167
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Vascular endothelial growth factor (VEGF) is a secreted endothelial cell-specific mitogen, which is induced by hypoxia and is angiogenic in vivo. Recently, elevated serum concentrations of VEGF (S-VEGF) have been reported in patients with cancers of various histologies. However, the prognostic significance of S-VEGF in human cancer is unknown and the origin of S-VEGF remains unsettled. We measured S-VEGF by enzyme-linked immunosorbent assay from sera taken from 82 patients with non-Hodgkin's lymphoma before treatment and stored for 9 to 15 years at -20 degrees C. All but one of the patients had been followed-up for at least 5 years or until death. S-VEGF ranged from 15 to 964 pg/mL; median, 228 pg/mL; mean, 291 pg/mL. A higher than the median S-VEGF level was associated with a poor World Health Organization performance status, a high International Prognostic Index, a high serum lactate dehydrogenase level, and a large cell histology, Patients with lower than the median S-VEGF at diagnosis had a 71% 5-year survival rate in comparison with only 49% among those with a higher than the median S-VEGF, We conclude that a high pretreatment S-VEGF level is associated with poor outcome in non-Hodgkin's lymphoma. (C) 1997 by The American Society of Hematology.
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页码:3167 / 3172
页数:6
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