Twenty single nucleotide polymorphisms (SNPs) and their allelic frequencies in four genes that are responsible for familial long QT syndrome in the Japanese population

被引：69

作者：

Iwasa, H

Itoh, T

Nagai, R

Nakamura, Y

Tanaka, T

机构：

[1] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab,Minato Ku, Tokyo 1088639, Japan

[2] Gunma Univ, Sch Med, Dept Internal Med 2, Gunma, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2000年 / 45卷 / 03期

关键词：

long QT syndrome; single nucleotide polymorphism; Japanese population; acquired arrhythmia; proarrhythmia;

D O I：

10.1007/s100380050207

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report here 20 single nucleotide polymorphisms (SNPs), including 10 novel ones, and their allelic frequencies detected in four genes that are known to be responsible for familial long QT syndrome in the Japanese population: 7 polymorphisms are in the KCNQ1 gene, 6 in the KCNH2 gene, 5 in the SCN5A gene, and 2 in the KCNE1 gene. These data will be of use for genetic association studies of acquired cardiac arrhythmias.

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页码：182 / 183

页数：2

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