What if there's no such thing as "aging"?

被引:28
作者
Cohen, Alan A. [1 ,3 ]
Legault, Veronique [1 ]
Fulop, Tamas [2 ,3 ]
机构
[1] Univ Sherbrooke, Dept Family Med, Grp Rech PRIMUS, 3001 12e Ave N, Sherbrooke, PQ J1H 5N4, Canada
[2] Univ Sherbrooke, Geriatr Div, Dept Med, 3001 12 Ave N, Sherbrooke, PQ J1H 5N4, Canada
[3] Res Ctr Aging, 1036 Rue Belvedere S, Sherbrooke, PQ J1H 4C4, Canada
基金
加拿大健康研究院;
关键词
Bow-tie; Complex systems; Information theory; Linguistics; Neural network; Paradigm; Philosophy of science; Sapir-Whorf; ALLOSTATIC LOAD; HALLMARKS; AGE; BIOMARKERS; SENESCENCE; EVOLUTION; NETWORKS; SCIENCE;
D O I
10.1016/j.mad.2020.111344
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
Are diseases caused by aging? What are the mechanisms of aging? Do all species age? These hotly debated questions revolve around a unitary definition of aging. Because we use the word "aging" so frequently, both colloquially and scientifically, we rarely pause to consider whether this word maps to an underlying biological phenomenon, or whether it is simply a grab-bag of diverse phenomena linked more by our mental associations than by any underlying biology. Here, we consider how the presence of the colloquial word "aging" generates a cognitive bias towards supposing there is a unitary biological phenomenon. We ask what kind of evidence would support or refute that idea, and subsequently show clear evidence at multiple levels that aging is not a unitary phenomenon. In particular, the known aging pathways lead to heterogeneous outputs, not a single coordinated phenomenon. From levels ranging from cellular/molecular to clinical to demographic to evolutionary, we show how the supposition that aging is a unitary phenomenon can mislead and distract us from asking the best questions. For major sub-disciplines of aging biology, we show how going beyond the notion of unitary aging can hone the paradigm and help advance the pace of discovery.
引用
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页数:9
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