Relationship between muscle sympathetic nerve activity and systemic hemodynamics during nitric oxide synthase inhibition in humans

被引:48
作者
Charkoudian, N.
Joyner, M. J.
Barnes, S. A.
Johnson, C. P.
Eisenach, J. H.
Dietz, N. M.
Wallin, B. G.
机构
[1] Mayo Clin, Coll Med, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Dept Anesthesiol, Rochester, MN 55905 USA
[3] Mayo Clin, Coll Med, Gen Clin Res Ctr, Rochester, MN 55905 USA
[4] Gothenburg Univ, Inst Clin Neurosci, S-41124 Gothenburg, Sweden
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2006年 / 291卷 / 03期
关键词
hypertension; cardiac output; sympathetic nervous system;
D O I
10.1152/ajpheart.00234.2006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Large interindividual differences exist in resting sympathetic nerve activity (SNA) among normotensive humans with similar arterial pressure (AP). We recently showed inverse relationships of resting SNA with cardiac output (CO) and vascular adrenergic responsiveness that appear to balance the influence of differences in SNA on blood pressure. In the present study, we tested whether nitric oxide (NO)-mediated vasodilation has a role in this balance by evaluating hemodynamic responses to systemic NO synthase (NOS) inhibition in individuals with low and high resting muscle SNA (MSNA). We measured MSNA via peroneal microneurography, CO via acetylene uptake and AP directly, at baseline and during increasing systemic doses of the NOS inhibitor NG-monomethyl-L-arginine (L-NMMA). Baseline MSNA ranged from 9 to 38 bursts/min (13 to 68 bursts/100 heartbeats). L-NMMA caused dose-dependent increases in AP and total peripheral resistance and reflex decreases in CO and MSNA. Increases in AP with L-NMMA were greater in individuals with high baseline MSNA (PANOVA < 0.05). For example, after 8.5 mg/kg of L-NMMA, in the low MSNA subgroup (n = 6, 28 +/- 4 bursts/100 heartbeats), AP increased 9 +/- 1 mmHg, whereas in the high-MSNA subgroup (n = 6, 58 +/- 3 bursts/100 heartbeats), AP increased 15 +/- 2 mmHg (P < 0.01). The high-MSNA subgroup had lower baseline CO and smaller decreases in CO with L-NMMA, but changes in total peripheral resistance were not different between groups. We conclude that differences in CO among individuals with varying sympathetic traffic have important hemodynamic implications during disruption of NO-mediated vasodilation.
引用
收藏
页码:H1378 / H1383
页数:6
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