Mechanisms of Disease: Psoriasis.

被引：2269

作者：

Nestle, Frank O. ^{[1
,2
]}

Kaplan, Daniel H. ^{[3
]}

Barker, Jonathan ^{[1
,2
]}

机构：

[1] Kings Coll London, St Johns Inst Dermatol, Natl Inst Hlth Res Biomed Res Ctr, Cutaneous Med Theme & Federat Clin Immunol Soc Ct, London WC2R 2LS, England

[2] St Thomas Fdn Trust, London, England

[3] Univ Minnesota, Dept Dermatol, Ctr Immunol, Minneapolis, MN 55455 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 361卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金; 美国国家卫生研究院;

关键词：

INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; ENDOTHELIAL GROWTH-FACTOR; DENDRITIC CELLS; DOUBLE-BLIND; T-CELLS; SUSCEPTIBILITY LOCUS; SKIN INFLAMMATION; CYTOKINE NETWORK; PLAQUE PSORIASIS; PATHOGENIC ROLE;

D O I：

10.1056/NEJMra0804595

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review emphasizes the pathologic features of psoriatic lesions, recent genetic studies of psoriasis, and immunologic factors in the disease. The evolution of a psoriatic lesion entails a complex interplay between environmental and genetic factors, which sets the scene for a cascade of events that activate dendritic cells and T cells. Cross-talk between epithelial cells and immune cells shapes and maintains the inflammatory milieu. Copyright © 2009 Massachusetts Medical Society.

引用

页码：496 / 509

页数：14

共 105 条

[1] A non-HLA gene within the MHC in psoriasis [J].