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Significant genetic linkage of MDR1 polymorphisms at positions 3435 and 2677:: Functional relevance to pharmacokinetics of digoxin

被引：100
作者：
Horinouchi, M
Sakaeda, T
Nakamura, T
Morita, Y
Tamura, T
Aoyama, N
Kasuga, M
Okumura, K
机构：
[1] Kobe Univ, Sch Med, Dept Hosp Pharm, Chuo Ku, Kobe, Hyogo 6500017, Japan
[2] Kobe Univ, Sch Med, Dept Clin Mol Med, Div Diabet Digest & Kidney Dis, Kobe, Hyogo 6500017, Japan
[3] Kobe Univ, Sch Med, Dept Endoscopy, Kobe, Hyogo 6500017, Japan
来源：
PHARMACEUTICAL RESEARCH | 2002年 / 19卷 / 10期
关键词：
MDR1; polymorphism; digoxin pharmacokinetics; genetic linkage;
D O I：
10.1023/A:1020433422259
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：1581 / 1585
页数：5
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  • [1] Biochemical, cellular, and pharmacological aspects of the multidrug transporter
    Ambudkar, SV
    Dey, S
    Hrycyna, CA
    Ramachandra, M
    Pastan, I
    Gottesman, MM
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1999, 39 : 361 - 398
  • [2] MDR1 pharmacogenetics:: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity
    Ameyaw, MM
    Regateiro, F
    Li, T
    Liu, XH
    Tariq, M
    Mobarek, A
    Thornton, N
    Folayan, GO
    Githang'a, J
    Indalo, A
    Ofori-Adjei, D
    Price-Evans, DA
    McLeod, HL
    [J]. PHARMACOGENETICS, 2001, 11 (03): : 217 - 221
  • [3] Effect of grapefruit juice on digoxin pharmacokinetics in humans
    Becquemont, L
    Verstuyft, C
    Kerb, R
    Brinkmann, U
    Lebot, M
    Jaillon, P
    Funck-Brentano, C
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 70 (04) : 311 - 316
  • [4] Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects
    Cascorbi, I
    Gerloff, T
    Johne, A
    Meisel, C
    Hoffmeyer, S
    Schwab, M
    Schaeffeler, E
    Eichelbaum, M
    Brinkmann, U
    Roots, I
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) : 169 - 174
  • [5] The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells
    Hitzl, M
    Drescher, S
    van der Kuip, H
    Schäffeler, E
    Fischer, J
    Schwab, M
    Eichelbaum, M
    Fromm, MF
    [J]. PHARMACOGENETICS, 2001, 11 (04): : 293 - 298
  • [6] Functional polymorphisms of the human multidrug-resistance gene:: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    Hoffmeyer, S
    Burk, O
    von Richter, O
    Arnold, HP
    Brockmöller, J
    Johne, A
    Cascorbi, I
    Gerloff, T
    Roots, I
    Eichelbaum, M
    Brinkmann, U
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) : 3473 - 3478
  • [7] Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects
    Ito, S
    Ieiri, I
    Tanabe, M
    Suzuki, A
    Higuchi, S
    Otsubo, K
    [J]. PHARMACOGENETICS, 2001, 11 (02): : 175 - 184
  • [8] Identification of functionally variant MDR1 alleles among European Americans and African Americans
    Kim, RB
    Leake, BF
    Choo, EF
    Dresser, GK
    Kubba, SV
    Schwarz, UI
    Taylor, A
    Xie, HG
    McKinsey, J
    Zhou, S
    Lan, LB
    Schuetz, JD
    Schuetz, EG
    Wilkinson, GR
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 70 (02) : 189 - 199
  • [9] P-GLYCOPROTEIN GENE (MDR1) CDNA FROM HUMAN ADRENAL - NORMAL P-GLYCOPROTEIN CARRIES GLY185 WITH AN ALTERED PATTERN OF MULTIDRUG RESISTANCE
    KIOKA, N
    TSUBOTA, J
    KAKEHI, Y
    KOMANO, T
    GOTTESMAN, MM
    PASTAN, I
    UEDA, K
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 162 (01) : 224 - 231
  • [10] Genetic polymorphism in MDR-1:: A tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors
    Mickley, LA
    Lee, JS
    Weng, Z
    Zhan, ZR
    Alvarez, M
    Wilson, W
    Bates, SE
    Fojo, T
    [J]. BLOOD, 1998, 91 (05) : 1749 - 1756
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