Sickle Cell Disease: New Opportunities and Challenges in Africa

被引：88

作者：

Makani, J. ^{[1
,2
]}

Ofori-Acquah, S. F. ^{[3
,4
]}

Nnodu, O. ^{[5
]}

Wonkam, A. ^{[6
,7
]}

Ohene-Frempong, K. ^{[8
]}

机构：

[1] Muhimbili Univ Hlth & Allied Sci, Dept Haematol & Blood Transfus, Dar Es Salaam, Tanzania

[2] Univ Oxford, Nuffield Dept Med, Oxford, England

[3] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA

[4] Univ Ghana, Sch Allied Hlth Sci, Coll Hlth Sci, Legon, Ghana

[5] Univ Abuja, Dept Haematol & Blood Transfus, Coll Hlth Sci, Abuja, Nigeria

[6] Univ Cape Town, Div Human Genet, Fac Heath Sci, ZA-7700 Rondebosch, South Africa

[7] Univ Yaounde I, Fac Med & Biomed Sci, Yaounde, Cameroon

[8] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

来源：

SCIENTIFIC WORLD JOURNAL | 2013年

关键词：

ACUTE SPLENIC SEQUESTRATION; ACUTE CHEST SYNDROME; PLASMODIUM-FALCIPARUM MALARIA; INVASIVE PNEUMOCOCCAL DISEASE; BONE-MARROW-TRANSPLANTATION; HUMAN PARVOVIRUS INFECTION; SILENT CEREBRAL INFARCTS; SUB-SAHARAN AFRICA; S-GLOBIN GENE; PULMONARY-HYPERTENSION;

D O I：

10.1155/2013/193252

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sickle cell disease (SCD) is one of the most common genetic causes of illness and death in the world. This is a review of SCD in Africa, which bears the highest burden of disease. The first section provides an introduction to the molecular basis of SCD and the pathophysiological mechanism of selected clinical events. The second section discusses the epidemiology of the disease (prevalence, morbidity, and mortality), at global level and within Africa. The third section discusses the laboratory diagnosis and management of SCD, emphasizing strategies that been have proven to be effective in areas with limited resources. Throughout the review, specific activities that require evidence to guide healthcare in Africa, as well as strategic areas for further research, will be highlighted.

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