Fluorine in a native protein environment -: How the spatial demand and polarity of fluoroalkyl groups affect protein folding

被引：132

作者：

Jaeckel, Christian ^{[1
]}

Salwiczek, Mario ^{[1
]}

Koksch, Beate ^{[1
]}

机构：

[1] Free Univ Berlin, Dept Chem & Biochem, D-14195 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 25期

关键词：

amino acids; fluorine; fluorous effect; peptides; protein modification;

D O I：

10.1002/anie.200504387

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Give and take: The influence of fluoro substitution of amino acid side chains on their interaction profile in a native polypeptide environment was studied systematically. The fluorination of alkyl groups has opposing electrostatic and steric consequences for the stability of hydrophobic protein cores. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4198 / 4203

页数：6

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