Ancient duplications of the human proglucagon gene

被引：31

作者：

Irwin, DM ^{[1
]}

机构：

[1] Univ Toronto, Fac Med, Banting & Best Diabet Ctr, Dept Lab Med & Pathobiol, Toronto, ON, Canada

来源：

GENOMICS | 2002年 / 79卷 / 05期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

gene families; genome evolution; pseudogene; gene duplication; EST; paralogy groups; 2R hypothesis;

D O I：

10.1006/geno.2002.6762

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The human proglucagon gene (GCG) is encoded within a finished 576-kb DNA sequence generated by the Human Genome Project. GCG is flanked by 18 kb and 65 kb of DNA, 5' and 3', respectively, that do not encode genes. The genomic sequence that includes GCG was found to have a long history of gene duplication events. Some members of the glucagon-like family of genes, GCG on chromosome 2 and GIP on chromosome 17, may be products of ancient genome duplications on the early vertebrate lineage. A large genomic tandem duplication event that included DPP4-like and GCG genes occurred before the amphibian-mammal divergence, but one of the duplicated copies of GCG has been lost on the human lineage. Recently, a processed pseudogene of the X-chromosome-linked gene TIMM8A was inserted downstream of GCG. Some ancient duplicates of GCG may retain physiological functions in other vertebrates.

引用

页码：741 / 746

页数：6

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