Enantioselective α-heterofunctionalisation of carbonyl compounds:: organocatalysis is the simplest approach

被引：278

作者：

Guillena, Gabriela ^{[1
]}

Ramon, Diego J. ^{[1
]}

机构：

[1] Univ Alicante, ISO, Dept Quim Organ, Fac Ciencias, E-03080 Alicante, Spain

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 10期

关键词：

D O I：

10.1016/j.tetasy.2006.05.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantioselective organocatalytic processes have reached maturity in recent years with an impressive number of applications now available. The application of these advantageous methodologies to the construction of chiral alpha-hetereofunctionalised carbonyl compounds allows us to obtain important chiral building blocks, such as a-amino acids, alpha-amino alcohols, aziridines, epoxides, 1,2-diols and alpha-sulfenylated, selenenylated and halogenated carbonyl derivatives. Proline, imidazolidinone derivatives, cinchona alkaloids and their ammonium salts, as well as Bronsted acid derivatives, have been used as chiral catalysts for these purposes. A survey of contributions in this field will be discussed throughout this review. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1465 / 1492

页数：28

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