Enantioselective α-heterofunctionalisation of carbonyl compounds:: organocatalysis is the simplest approach

被引:277
作者
Guillena, Gabriela [1 ]
Ramon, Diego J. [1 ]
机构
[1] Univ Alicante, ISO, Dept Quim Organ, Fac Ciencias, E-03080 Alicante, Spain
关键词
D O I
10.1016/j.tetasy.2006.05.020
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Enantioselective organocatalytic processes have reached maturity in recent years with an impressive number of applications now available. The application of these advantageous methodologies to the construction of chiral alpha-hetereofunctionalised carbonyl compounds allows us to obtain important chiral building blocks, such as a-amino acids, alpha-amino alcohols, aziridines, epoxides, 1,2-diols and alpha-sulfenylated, selenenylated and halogenated carbonyl derivatives. Proline, imidazolidinone derivatives, cinchona alkaloids and their ammonium salts, as well as Bronsted acid derivatives, have been used as chiral catalysts for these purposes. A survey of contributions in this field will be discussed throughout this review. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1465 / 1492
页数:28
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