Nitric oxide accounts for an increased glycolytic rate in activated astrocytes through a glycogenolysis-independent mechanism

被引：7

作者：

Almeida, A

Cidad, P

Bolaños, JP

机构：

[1] Univ Salamanca, Dept Bioquim & Biol Mol, Edificio Dept, Salamanca 37007, Spain

[2] Hosp Univ Salamanca, Unidad Invest, Salamanca, Spain

来源：

BRAIN RESEARCH | 2002年 / 945卷 / 01期

关键词：

nitric oxide; astrocyte; glycolysis; glycogen;

D O I：

10.1016/S0006-8993(02)02877-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The possible interference of nitric oxide (NO) in glucose metabolism was studied in activated astrocytes. Lipopolysaccharide (LPS) treatment triggered a NO-mediated increase in glucose consumption and lactate production, suggesting an enhanced rate of glycolysis. Active glycogen synthesis was also observed after LPS treatment, but NO synthase inhibition was unable to prevent this effect. These results strongly suggest that endogenously-formed NO stimulates glycolysis through a glycogenolysis-independent mechanism in astrocytes. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：131 / 134

页数：4

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