The synthesis of gem-cyclopentyl substituted glutarates via the oxidative ring contraction of 2-acetylcyclohexanones

被引：2

作者：

Challenger, S ^{[1
]}

Derrick, A ^{[1
]}

Silk, TV ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Sandwich CT13 9NJ, Kent, England

来源：

SYNTHETIC COMMUNICATIONS | 2002年 / 32卷 / 19期

关键词：

oxidative ring-contraction; hydrogen peroxide; preparation of cyclopentyl substituted glutarates;

D O I：

10.1081/SCC-120012979

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A two stop synthesis of differentially protected gem.-cyclopentyl glutarates has been developed from 2-acetylcyclohexanone and acrylates. The key step involves an oxidative ring contraction reaction with hydrogen peroxide. The methodology has been used to prepare intermediates used in the preparation of the atriopeptidase inhibitor candoxatril.

引用

页码：2911 / 2918

页数：8

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