Versatile synthesis of chiral aminophosphine phosphinites (AMPPs) as ligands for enantioselective hydrogenation

被引：11

作者：

Dubrovina, NV

Tararov, VI

Kadyrova, Z

Monsees, A

Börner, A

机构：

[1] Univ Rostock EV, Leibniz Inst Organ Katalyse, D-18055 Rostock, Germany

[2] Degussa AG, D-65926 Frankfurt, Germany

[3] Univ Rostock, Fachbereich Chem, D-18059 Rostock, Germany

来源：

SYNTHESIS-STUTTGART | 2004年 / 12期

关键词：

hydrogenation; transition metals; asymmetric catalysis; amino alcohols; phosphorus;

D O I：

10.1055/s-2004-829183

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New chiral aminophosphine phosphinite (AMPP) ligands with different P-aryl substituents were prepared from (1R,3S,4S)-2-azabicyclo[2.2.1]hept-3-ylmethanol by a new and chemoselective synthetic approach. The ligands showed good enantioselectivity (up to 91%) in the Rh-catalyzed enantioselective hydrogenation of benchmark substrates.

引用

页码：2047 / 2051

页数：5

共 18 条

[1] Chiral aminophosphine phosphinite ligands and related auxiliaries - Recent advances in their design, coordination chemistry, and use in enantioselective catalysis [J].