Cholinergic system regulation of spatial representation by the hippocampus

被引:75
作者
Ikonen, S
McMahan, R
Gallagher, M
Eichenbaum, H
Tanila, H
机构
[1] Univ Kuopio, Dept Neurosci & Neurol, FIN-70211 Kuopio, Finland
[2] Kuopio Univ Hosp, SF-70210 Kuopio, Finland
[3] Johns Hopkins Univ, Dept Psychol, Baltimore, MD 21218 USA
[4] Boston Univ, Dept Psychol, Boston, MA 02215 USA
关键词
acetylcholine; hippocampus; place cells; immunotoxic lesion; spatial learning; spatial memory;
D O I
10.1002/hipo.1109
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The role of the basal forebrain cholinergic system in hippocampal spatial representation was explored by examining the effects of immunotoxic lesions of the septo-hippocampal cholinergic neurons on the firing patterns of hippocampal place cells as rats explored familiar and novel environments. In a highly familiar environment, the basic qualities and stability of place fields were unaffected by the lesion. When first exposed to a set of novel environmental cues without otherwise disorienting the animals, place cells in both normal and lesioned animals responded with similar alterations in their firing patterns. Upon subsequent repetitive exposures to the new environment, place cells of normal rats developed a spatial representation distinct from that of the familiar environment. By contrast, place cells of lesioned animals reconverged in the direction of the representation associated with the familiar environment. These results suggest that cholinergic input may determine whether new visual information or a stored representation of the current environment will be actively processed in the hippocampal network.
引用
收藏
页码:386 / 397
页数:12
相关论文
共 63 条
[1]   LEARNING AND MEMORY [J].
ALKON, DL ;
AMARAL, DG ;
BEAR, MF ;
BLACK, J ;
CAREW, TJ ;
COHEN, NJ ;
DISTERHOFT, JF ;
EICHENBAUM, H ;
GOLSKI, S ;
GORMAN, LK ;
LYNCH, G ;
MCNAUGHTON, BL ;
MISHKIN, M ;
MOYER, JR ;
OLDS, JL ;
OLTON, DS ;
OTTO, T ;
SQUIRE, LR ;
STAUBLI, U ;
THOMPSON, LT ;
WIBLE, C .
BRAIN RESEARCH REVIEWS, 1991, 16 (02) :193-220
[2]   AGING IS ASSOCIATED WITH A DIFFUSE IMPAIRMENT OF FOREBRAIN CHOLINERGIC NEURONS [J].
ALTAVISTA, MC ;
ROSSI, P ;
BENTIVOGLIO, AR ;
CROCIANI, P ;
ALBANESE, A .
BRAIN RESEARCH, 1990, 508 (01) :51-59
[3]   THE 3-DIMENSIONAL ORGANIZATION OF THE HIPPOCAMPAL-FORMATION - A REVIEW OF ANATOMICAL DATA [J].
AMARAL, DG ;
WITTER, MP .
NEUROSCIENCE, 1989, 31 (03) :571-591
[4]   MUSCARINIC MODULATION OF INTRINSIC BURST FIRING IN RAT HIPPOCAMPAL-NEURONS [J].
AZOUZ, R ;
JENSEN, MS ;
YAARI, Y .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (06) :961-966
[5]   PHYSIOLOGICAL COMPENSATION FOR LOSS OF AFFERENT SYNAPSES IN RAT HIPPOCAMPAL GRANULE CELLS DURING SENESCENCE [J].
BARNES, CA ;
MCNAUGHTON, BL .
JOURNAL OF PHYSIOLOGY-LONDON, 1980, 309 (DEC) :473-485
[6]   THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].
BARTUS, RT ;
DEAN, RL ;
BEER, B ;
LIPPA, AS .
SCIENCE, 1982, 217 (4558) :408-417
[7]   SELECTIVE IMMUNOLESION OF THE BASAL FOREBRAIN CHOLINERGIC NEURONS - EFFECTS ON HIPPOCAMPAL ACTIVITY DURING SLEEP AND WAKEFULNESS IN THE RAT [J].
BASSANT, MH ;
APARTIS, E ;
JAZATPOINDESSOUS, FR ;
WILEY, RG ;
LAMOUR, YA .
NEURODEGENERATION, 1995, 4 (01) :61-70
[8]   SELECTIVE IMMUNOTOXIC LESIONS OF BASAL FOREBRAIN CHOLINERGIC CELLS - EFFECTS ON LEARNING AND MEMORY IN RATS [J].
BAXTER, MG ;
BUCCI, DJ ;
WILEY, RG ;
GORMAN, LK ;
GALLAGHER, M .
BEHAVIORAL NEUROSCIENCE, 1995, 109 (04) :714-722
[9]  
BERGERSWEENEY J, 1994, J NEUROSCI, V14, P4507
[10]   THE PHYSIOLOGY AND PHARMACOLOGY OF HIPPOCAMPAL-FORMATION THETA RHYTHMS [J].
BLAND, BH .
PROGRESS IN NEUROBIOLOGY, 1986, 26 (01) :1-54