Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo

被引：54

作者：

Heringer-Walther, Silvia ^{[2
]}

Eckert, Klaus ^{[3
]}

Schumacher, Sarah-Mai ^{[4
]}

Uharek, Lutz ^{[5
]}

Wulf-Goldenberg, Annika ^{[3
]}

Gembardt, Florian ^{[1
,6
]}

Fichtner, Iduna ^{[3
]}

Schultheiss, Heinz-Peter ^{[4
]}

Rodgers, Kathy ^{[7
]}

Walther, Thomas ^{[1
,6
]}

机构：

[1] Univ Hull, Hull York Med Sch, Ctr Biomed Res, Kingston Upon Hull HU6 7RX, N Humberside, England

[2] Univ Leipzig, Dept Gynaecol, Leipzig, Germany

[3] Max Delbruck Ctr, Berlin, Germany

[4] Charite Univ Med Berlin, Dept Cardiol, Berlin, Germany

[5] Charite Univ Med Berlin, Dept Haematol, Berlin, Germany

[6] Erasmus MC, Dept Pharmacol, Rotterdam, Netherlands

[7] Univ So Calif, Dept Obstet & Gynecol, Los Angeles, CA 90089 USA

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2009年 / 94卷 / 06期

关键词：

angiotensin; CD34; hematopoietic stem cell; NITRIC-OXIDE SYNTHASE; RECOVERY; ACTIVATION; PEPTIDES;

D O I：

10.3324/haematol.2008.000034

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34(+) and mononuclear cells in vitro. Under ill vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+ and CD34(+) cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.

引用

页码：857 / 860

页数：4

共 10 条

[1]

Synergistic effects of co-administration of angiotensin 1-7 and Neupogen on hematopoietic recovery in mice [J].

Ellefson, DD ;

diZerega, GS ;

Espinoza, T ;

Roda, N ;

Maldonado, S ;

Rodgers, KE .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2004, 53 (01) :15-24

[2]

Angiotensin I, angiotensin II and their biologically active peptides [J].

Ferrario, CM .

JOURNAL OF HYPERTENSION, 2002, 20 (05) :805-807

[3]

Effect of angiotensin II and angiotensin(1-7) on hematopoietic recovery after intravenous chemotherapy [J].

Rodgers, K ;

Xiong, SQ ;

diZerega, GS .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2003, 51 (02) :97-106

[4]

Effect of angiotensin II on hematopoietic progenitor cell proliferation [J].

Rodgers, KE ;

Xiong, S ;

Steer, R ;

diZerega, GS .

STEM CELLS, 2000, 18 (04) :287-294

[5]

Accelerated recovery from irradiation injury by angiotensin peptides [J].

Rodgers, KE ;

Xiong, SQ ;

diZerega, GS .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2002, 49 (05) :403-411

[6]

Activation of endothelial nitric oxide synthase is critical for erythropoietin-induced mobilization of progenitor cells [J].

Santhanam, Anantha Vijay R. ;

d'Uscio, Livius V. ;

Peterson, Timothy E. ;

Katusic, Zvonimir S. .

PEPTIDES, 2008, 29 (08) :1451-1455

[7]

Effects of angiotensin II skin wound healing receptor signaling during [J].

Takeda, H ;

Katagata, Y ;

Hozumi, Y ;

Kondo, S .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (05) :1653-1662

[8]

Unger T, 1996, J HYPERTENS, V14, pS95

[9]

Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia [J].

Urao, Norifumi ;

Okigaki, Mitsuhiko ;

Yamada, Hiroyuki ;

Aadachi, Yasushi ;

Matsuno, Kuniharu ;

Matsui, Akihiro ;

Matsunaga, Shinsaku ;

Tateishi, Kento ;

Nomura, Tetsuya ;

Takahashi, Tomosaburo ;

Tatsumi, Tetsuya ;

Matsubara, Hiroaki .

CIRCULATION RESEARCH, 2006, 98 (11) :1405-1413

[10]

Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells [J].

Zambidis, Elias T. ;

Park, Tea Soon ;

Yu, Wayne ;

Tam, Ada ;

Levine, Michal ;

Yuan, Xuan ;

Pryzhkova, Marina ;

Peault, Bruno .

BLOOD, 2008, 112 (09) :3601-3614

← 1 →