Synthesis of aziridinomitosenes through base-catalyzed conjugate addition

被引：19

作者：

Tsuboike, K ^{[1
]}

Guerin, DJ ^{[1
]}

Mennen, SM ^{[1
]}

Miller, SJ ^{[1
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA

来源：

TETRAHEDRON | 2004年 / 60卷 / 34期

关键词：

aziridinomitosene; conjugate addition; peptide; organocatalyst;

D O I：

10.1016/j.tet.2004.06.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of an aziridinomitosene core structure that relies on a facile tertiary-amine base-catalyzed azide conjugate addition is reported. Straightforward derivatization of the conjugate addition product affords the desired mitomycin ring system. Initial catalyst screens have identified peptides that afford the product with modest enantioselectivities. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7367 / 7374

页数：8

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