New Antithrombotic Drugs

被引：83

作者：

Gross, P. L. ^{[1
,2
]}

Weitz, J. I. ^{[1
,2
,3
]}

机构：

[1] McMaster Univ, Dept Med, Hamilton, ON, Canada

[2] Henderson Res Ctr, Hamilton, ON, Canada

[3] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 86卷 / 02期

关键词：

ACUTE CORONARY SYNDROMES; ORAL DIRECT THROMBIN; NONVALVULAR ATRIAL-FIBRILLATION; THROMBOXANE RECEPTOR ANTAGONIST; FACTOR XA INHIBITOR; VENOUS THROMBOEMBOLISM; DABIGATRAN ETEXILATE; TOTAL HIP; DOUBLE-BLIND; P2Y(12) RECEPTOR;

D O I：

10.1038/clpt.2009.98

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thrombosis, both venous and arterial, is a major cause of morbidity and mortality worldwide. Consequently, there is an ongoing search for new antithrombotic drugs, particularly novel antiplatelet agents and anticoagulants. A better understanding of the biochemical pathways involved in platelet activation and coagulation and of the links between these systems and the impact of thrombosis on inflammation has led to the identification of new targets for antithrombotic drugs. This paper focuses on these new targets and new antiplatelet drugs and anticoagulants and describes the major advances in the continuing search for more potent antithrombotic drugs that have limited effects on hemostasis.

引用

页码：139 / 146

页数：8

共 74 条

[1] Oral anticoagulant therapy in patients with coronary artery disease: A meta-analysis [J].

Anand, SS ;

Yusuf, S .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (21) :2058-2067

[2] Oral anticoagulants in patients with coronary artery disease [J].

Anand, SS ;

Yusuf, S .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (04) :62S-69S

[3] Factor Xa or thrombin: is factor Xa a better target? [J].

Ansell, J. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 :60-64

[4] The pharmacology and management of the vitamin K antagonists [J].

Ansell, J ;

Hirsh, J ;

Poller, L ;

Bussey, H ;

Jacobson, A ;

Hylek, E .

CHEST, 2004, 126 (03) :204S-233S

[5] Pharmacology and management of the vitamin K antagonists [J].

Ansell, Jack ;

Hirsh, Jack ;

Hylek, Elaine ;

Jacobson, Alan ;

Crowther, Mark ;

Palareti, Gualtiero .

CHEST, 2008, 133 (06) :160S-198S

[6] The primary and secondary prevention of coronary artery disease [J].

Becker, Richard C. ;

Meade, Thomas W. ;

Berger, Peter B. ;

Ezekowitz, Michael ;

O'Connor, Christopher M. ;

Vorchheimer, David A. ;

Guyatt, Gordon H. ;

Mark, Daniel B. ;

Harrington, Robert A. .

CHEST, 2008, 133 (06) :776S-814S

[7] Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study [J].

Becker, Richard C. ;

Moliterno, David J. ;

Jennings, Lisa K. ;

Pieper, Karen S. ;

Pei, Jinglan ;

Niederman, Alan ;

Ziada, Khaled M. ;

Berman, Gail ;

Strony, John ;

Joseph, Diane ;

Mahaffey, Kenneth W. ;

Van de Werf, Frans ;

Veltri, Enrico ;

Harrington, Robert A. .

LANCET, 2009, 373 (9667) :919-928

[8] Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events [J].

Bhatt, DL ;

Fox, KAA ;

Hacke, W ;

Berger, PB ;

Black, HR ;

Boden, WE ;

Cacoub, P ;

Cohen, EA ;

Creager, MA ;

Easton, JD ;

Flather, MD ;

Haffner, SM ;

Hamm, CW ;

Hankey, GJ ;

Johnston, SC ;

Mak, KH ;

Mas, JL ;

Montalescot, G ;

Pearson, TA ;

Steg, PG ;

Steinhubl, SR ;

Weber, MA ;

Brennan, DM ;

Fabry-Ribaudo, L ;

Booth, J ;

Topol, EJ ;

Frye, RL ;

Amarenco, P ;

Brass, LM ;

Buyse, M ;

Cohen, LS ;

DeMets, DL ;

Fuster, V ;

Hart, RG ;

Marler, JR ;

McCarthy, C ;

Schoemig, A ;

Lincoff, AM ;

Brener, SJ ;

Sila, CA ;

Albuquerque, A ;

Aroutiounov, G ;

Artemiev, D ;

Atkeson, BG ;

Bartel, T ;

Basart, DCG ;

Lima, AB ;

Belli, G ;

Bordalo e Sa, AL ;

Bosch, X .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (16) :1706-1717

[9] The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans [J].

Blech, Stefan ;

Ebner, Thomas ;

Ludwig-Schwellinger, Eva ;

Stangier, Joachim ;

Roth, Willy .

DRUG METABOLISM AND DISPOSITION, 2008, 36 (02) :386-399

[10]

Bouchard BA, 2007, PLATELETS, 2ND EDITION, P377, DOI 10.1016/B978-012369367-9/50781-3

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