Histopathologic study of eyes after iodine I 125 episcleral plaque irradiation for uveal melanoma

被引:19
作者
Saornil, MA
Fisher, MR
Campbell, RJ
Robertson, DM
Earle, JD
Eagle, RC
Shields, JA
Shields, CL
Chandra, SR
Albert, DM
机构
[1] UNIV WISCONSIN,SCH MED,DEPT OPHTHALMOL & VISUAL SCI,MADISON,WI 53792
[2] UNIV WISCONSIN,SCH MED,DEPT BIOSTAT,MADISON,WI 53792
[3] UNIV VALLADOLID,DEPT OPHTHALMOL,INST OFTALMOBIOL APLICADA,VALLADOLID,SPAIN
[4] MAYO CLIN & MAYO FDN,DEPT LAB MED & PATHOL,ROCHESTER,MN 55905
[5] MAYO CLIN & MAYO FDN,DEPT OPHTHALMOL,ROCHESTER,MN 55905
[6] MAYO CLIN & MAYO FDN,DEPT RADIOTHERAPY,ROCHESTER,MN 55905
[7] THOMAS JEFFERSON UNIV,WILLS EYE HOSP,DEPT OPHTHALMOL,PHILADELPHIA,PA 19107
关键词
D O I
10.1001/archopht.1997.01100160565006
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objectives: To describe the histopathologic findings attributable to irradiation in eyes with uveal malignant melanoma treated with iodine I 125 brachytherapy and to compare these findings with those reviewed in a previous study that compared histopathologic findings in eyes enucleated after pro ton beam teletherapy with those seen in eyes in a nonirradiated control group. Methods: The slides from 22 eyes with uveal melanoma that had undergone enucleation after the administration of I-125 brachytherapy were studied. The histopathologic features of the tumor and the retina were graded. Results were compared with findings from a previously reported group of 47 proton beam-treated eyes and its control group. Results: Patient age, time between irradiation and enucle ation, and ciliary body involvement were similar for the I-125 brachytherapy-treated group and the proton beam-treated group and its control group. This allows comparison of the histopathologic findings. Comparing the I-125 brachytherapy-and proton beam-treated groups, most histopathologic features were similar with nominally statistically significant differences only for cell type, number of mitotic figures, and fibrous metaplasia of the retinal pigment epithelium adjacent to the tumor. Conclusions: Irradiation of uveal melanoma induces changes in the tumor and in the surrounding retina. Brachytherapy and charged particle therapy are the 2 principal methods of irradiation. This study demonstrates that similar changes are produced by I-125 plaque irradiation and proton beam irradiation.
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页码:1395 / 1400
页数:6
相关论文
共 30 条
[1]   The ocular melanoma story - LIII Edward Jackson Memorial Lecture .2. [J].
Albert, DM .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1997, 123 (06) :729-741
[2]  
ALBERT DM, IN PRESS AM J OPHTHA
[3]  
CHAR DH, 1983, ARCH OPHTHALMOL-CHIC, V101, P236
[4]  
*COLL OC MEL STUD, 1993, CONTROLLED CLIN TRIA, V14, P362
[5]  
CRAWFORD JB, 1987, OPHTHALMOLOGY, V94, P639
[6]  
EARLE J, 1987, ARCH OPHTHALMOL-CHIC, V105, P763
[7]  
FERRY AP, 1985, ARCH OPHTHALMOL-CHIC, V103, P1849
[8]  
Fisher L.D., 1993, BIOSTATISTICS METHOD
[9]  
FUCHS U, 1988, ACTA OPHTHALMOL, V66, P255
[10]   UVEAL MELANOMA NECROSIS AFTER HELIUM ION THERAPY [J].
GOODMAN, DF ;
CHAR, DH ;
CRAWFORD, JB ;
STONE, RD ;
CASTRO, JR .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 1986, 101 (06) :643-645