Alkenenitriles:: Annulations with ω-chloro Grignard reagents

被引：14

作者：

Fleming, FF ^{[1
]}

Zhang, ZY ^{[1
]}

Wang, QZ ^{[1
]}

Steward, OW ^{[1
]}

机构：

[1] Duquesne Univ, Dept Chem & Biochem, Pittsburgh, PA 15282 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 15期

关键词：

D O I：

10.1021/ol0261175

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] omega-Chloro Grignard reagents chelate with cyclic gamma-hydroxy-alpha,beta-alkenenitriles to trigger a conjugate addition-alkylation annulation. The chelation-controlled conjugate addition-alkylation is the first anionic annulation with alpha,beta-alkenenitriles, providing cis bicyclo[3.3.0]octane, hydrindane, and decalin ring systems in a single synthetic operation.

引用

页码：2493 / 2495

页数：3

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