When transcription and repair meet:: a complex system

被引：122

作者：

Laine, Jean-Philippe ^{[1
]}

Egly, Jean-Marc ^{[1
]}

机构：

[1] ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

来源：

TRENDS IN GENETICS | 2006年 / 22卷 / 08期

关键词：

D O I：

10.1016/j.tig.2006.06.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Transcription-coupled repair (TCR) is a mechanism that removes DNA lesions so that genes can be transcribed correctly. However, the sequence of events that results in a DNA lesion being repaired remains elusive. In this review, we illustrate the potential chain of events leading to the elimination of the damaged DNA and the proper resumption of transcription. We focus on the roles of CSA and CSB proteins, which, when mutated, impair TCR. Defective TCR is one of the features of Cockayne syndrome, a DNA-repair disorder.

引用

页码：430 / 436

页数：7

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