Exosome-mediated microenvironment dysregulation in leukemia

被引：79

作者：

Kumar, Bijender ^{[1
]}

Garcia, Mayra ^{[1
]}

Murakami, Jodi L. ^{[1
]}

Chen, Ching-Cheng ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, Irell & Manella Grad Sch Biol Sci, Gehr Family Ctr Leukemia Res, Div Hematopoiet Stem Cell & Leukemia Res,Beckman, Duarte, CA 91010 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2016年 / 1863卷 / 03期

关键词：

Exosomes; Niche; Leukemia cell; Hematopoietic stem cells; HEMATOPOIETIC STEM-CELLS; STROMAL CELLS; BETA-CATENIN; KINASE INHIBITORS; PREVENT APOPTOSIS; PROGENITOR CELLS; CANCER EXOSOMES; SELF-RENEWAL; N-CADHERIN; NICHE;

D O I：

10.1016/j.bbamcr.2015.09.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The hematopoietic stem cell (HSC) niche is composed of a complex set of stromal support cells that maintain HSCs and promote normal hematopoiesis. We now know that molecular changes within the hematopoietic niche contribute to leukemia development. Leukemia cells often reorganize the hematopoietic niche to promote and support their own survival and growth. Here we will summarize recent works that decipher the normal hematopoietic niche cellular components and describe how the leukemia-transformed niche contributes to hematological malignances. Finally, we will discuss recent publications that highlight a possible role for exosomes in the leukemia-induced niche reorganization. This article is part of a Special Issue entitled: Tumor Microenvironment Regulation of Cancer Cell Survival, Metastasis, Inflammation, and Immune Surveillance edited by Peter Ruvolo and Gregg L. Semenza. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：464 / 470

页数：7

共 78 条

[1]

Microvesicles Messengers and mediators of tumor progression [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Rak, Janusz .

CELL CYCLE, 2009, 8 (13) :2014-2018

[2]

BENDALL LJ, 1994, EXP HEMATOL, V22, P1252

[3]

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways [J].

Boelens, Mirjam C. ;

Wu, Tony J. ;

Nabet, Barzin Y. ;

Xu, Bihui ;

Qiu, Yu ;

Yoon, Taewon ;

Azzam, Diana J. ;

Victor, Christina Twyman-Saint ;

Wiemann, Brianne Z. ;

Ishwaran, Hemant ;

ter Brugge, Petra J. ;

Jonkers, Jos ;

Slingerland, Joyce ;

Minn, Andy J. .

CELL, 2014, 159 (03) :499-513

[4]

Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development [J].

Bowers, Marisa ;

Zhang, Bin ;

Ho, Yinwei ;

Agarwal, Puneet ;

Chen, Ching-Cheng ;

Bhatia, Ravi .

BLOOD, 2015, 125 (17) :2678-2688

[5]

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion [J].

Bruns, Ingmar ;

Lucas, Daniel ;

Pinho, Sandra ;

Ahmed, Jalal ;

Lambert, Michele P. ;

Kunisaki, Yuya ;

Scheiermann, Christoph ;

Schiff, Lauren ;

Poncz, Mortimer ;

Bergman, Aviv ;

Frenette, Paul S. .

NATURE MEDICINE, 2014, 20 (11) :1315-1320

[6]

Osteoblastic cells regulate the haematopoietic stem cell niche [J].

Calvi, LM ;

Adams, GB ;

Weibrecht, KW ;

Weber, JM ;

Olson, DP ;

Knight, MC ;

Martin, RP ;

Schipani, E ;

Divieti, P ;

Bringhurst, FR ;

Milner, LA ;

Kronenberg, HM ;

Scadden, DT .

NATURE, 2003, 425 (6960) :841-846

[7]

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling [J].

Chairoungdua, Arthit ;

Smith, Danielle L. ;

Pochard, Pierre ;

Hull, Michael ;

Caplan, Michael J. .

JOURNAL OF CELL BIOLOGY, 2010, 190 (06) :1079-1091

[8]

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB [J].

Chow, Amy ;

Zhou, Weiying ;

Liu, Liang ;

Fong, Miranda Y. ;

Champer, Jackson ;

Van Haute, Desiree ;

Chin, Andrew R. ;

Ren, Xiubao ;

Gugiu, Bogdan Gabriel ;

Meng, Zhipeng ;

Huang, Wendong ;

Ngo, Vu ;

Kortylewski, Marcin ;

Wang, Shizhen Emily .

SCIENTIFIC REPORTS, 2014, 4

[9]

Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche [J].

Chow, Andrew ;

Lucas, Daniel ;

Hidalgo, Andres ;

Mendez-Ferrer, Simon ;

Hashimoto, Daigo ;

Scheiermann, Christoph ;

Battista, Michela ;

Leboeuf, Marylene ;

Prophete, Colette ;

van Rooijen, Nico ;

Tanaka, Masato ;

Merad, Miriam ;

Frenette, Paul S. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (02) :261-271

[10]

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches [J].

Ding, Lei ;

Morrison, Sean J. .

NATURE, 2013, 495 (7440) :231-235

← 1 2 3 4 5 6 7 8 →