Antimycobacterial activity of econazole against multidrug-resistant strains of Mycobacterium tuberculosis

被引：50

作者：

Ahmad, Zahoor

Sharma, Sadhna

Khuller, G. K. ^{[1
]}

Singh, Pushpendra

Faujdar, Jaya

Katoch, V. M.

机构：

[1] Postgrad Inst Med Educ & Res, Dept Biochem, Chandigarh 160012, India

[2] Natl Jalma Inst Leprosy & Other Mycobacterial Dis, Dept Med Microbiol, Agra 282001, Uttar Pradesh, India

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2006年 / 28卷 / 06期

关键词：

econazole; multidrug resistance; Mycobacterium tuberculosis; antimycobacterials;

D O I：

10.1016/j.ijantimicag.2006.07.028

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study evaluated the anti mycobacterial activity of econazole against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis. The minimum inhibitory concentration (MIC90) and minimum bactericidal concentration (MBC (> 99.99)) against MDR strains were found to be 0.120-0.125 mu g/mL and 0.125-0.150 mu g/mL, respectively, demonstrating the anti mycobacterial potential of econazole. (c) 2006 Published by Elsevier B.V. and the International Society of Chemotherapy.

引用

页码：543 / 544

页数：2

共 6 条

[1] The potential of azole antifungals against latent/persistent tuberculosis [J].

Ahmad, Z ;

Sharma, S ;

Khuller, GK .

FEMS MICROBIOLOGY LETTERS, 2006, 258 (02) :200-203

[2]

DAVID L, 2003, J BIOL CHEM, V278, P5141

[3] Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes [J].

McLean, KJ ;

Marshall, KR ;

Richmond, A ;

Hunter, IS ;

Fowler, K ;

Kieser, T ;

Gurcha, SS ;

Besra, GS ;

Munro, AW .

MICROBIOLOGY-SGM, 2002, 148 :2937-2949

[4] BACTERIOLOGICAL INVESTIGATIONS FOR SHORT-COURSE CHEMOTHERAPY UNDER THE TUBERCULOSIS PROGRAM IN 2 DISTRICTS OF INDIA [J].

PARAMASIVAN, CN ;

CHANDRASEKARAN, V ;

SANTHA, T ;

SUDARSANAM, NM ;

PRABHAKAR, R .

TUBERCLE AND LUNG DISEASE, 1993, 74 (01) :23-27

[5]

Zahoor A., 2005, FEMS MICROBIOL LETT, V251, P19

[6]

Zahoor A., 2006, FEMS MICROBIOL LETT, V261, P181

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