Identification of a splice variant of the rat estrogen receptor beta gene

被引：144

作者：

Chu, S ^{[1
]}

Fuller, PJ ^{[1
]}

机构：

[1] PRINCE HENRYS INST MED RES,CLAYTON,VIC 3168,AUSTRALIA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1997年 / 132卷 / 1-2期

关键词：

estrogen; ligand-binding domain; isoforms; steroid receptors;

D O I：

10.1016/S0303-7207(97)00133-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recently a second estrogen receptor termed estrogen receptor beta (ER beta) has been cloned and characterized, and shown to be expressed al the highest levels in ovarian granulosa cells and prostatic epithelium. In the course of amplifying a region of the ligand-binding domain of the rat ER beta cDNA we identified a second, larger transcript which appears to arise through differential splicing. The second isoform has 54 nucleotides inserted after position 1372 encoding 18 additional amino acids. Both isoforms are expressed al similar relative abundance in a range of tissues. (C) 1997 Elsevier Science Ireland Ltd.

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页码：195 / 199

页数：5

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