Modulation of brain reward circuitry by leptin

被引：310

作者：

Fulton, S ^{[1
]}

Woodside, B ^{[1
]}

Shizgal, P ^{[1
]}

机构：

[1] Concordia Univ, Ctr Studies Behav Neurobiol, Montreal, PQ H3G 1M8, Canada

来源：

SCIENCE | 2000年 / 287卷 / 5450期

关键词：

D O I：

10.1126/science.287.5450.125

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Leptin, a hormone secreted by fat cells, suppresses food intake and promotes weight Loss, To assess the action of this hormone on brain reward circuitry, changes in the rewarding effect of Lateral hypothalamic stimulation were measured after leptin administration. At five stimulation sites near the fornix, the effectiveness of the rewarding electrical stimulation was enhanced by chronic food restriction and attenuated by intracerebroventricular infusion of leptin. In contrast, the rewarding effect of stimulating neighboring sites was insensitive to chronic food restriction and was enhanced by leptin in three of four cases. These opposing effects of Leptin may mirror complementary changes in the rewarding effects of feeding and of competing behaviors.

引用

页码：125 / 128

页数：4

共 34 条

[1] CURVE-SHIFT ANALYSIS OF SELF-STIMULATION IN FOOD-RESTRICTED RATS - RELATIONSHIP BETWEEN DAILY MEAL, PLASMA-CORTICOSTERONE AND REWARD SENSITIZATION
ABRAHAMSEN, GC
BERMAN, Y
CARR, KD
[J]. BRAIN RESEARCH, 1995, 695 (02) : 186 - 194
[2] Arvanitogiannis A, 1999, PHYSIOL BEHAV, V65, P805
[3] Effects of excitotoxic lesions of the basal forebrain on MFB self-stimulation
Arvanitogiannis, A
Waraczynski, M
Shizgal, P
[J]. PHYSIOLOGY & BEHAVIOR, 1996, 59 (4-5) : 795 - 806
[4] RELATIVE EFFECTS OF NUTRITIONAL DEFICIT AND DEPRIVATION PERIOD ON RATE OF ELECTRICAL SELF-STIMULATION OF LATERAL HYPOTHALAMUS
BLUNDELL, JE
HERBERG, LJ
[J]. NATURE, 1968, 219 (5154) : 627 - &
[5] Broberger C, 1998, J COMP NEUROL, V402, P460
[6] RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS
CAMPFIELD, LA
SMITH, FJ
GUISEZ, Y
DEVOS, R
BURN, P
[J]. SCIENCE, 1995, 269 (5223) : 546 - 549
[7] CHRONIC FOOD RESTRICTION AND WEIGHT-LOSS PRODUCE OPIOID FACILITATION OF PERIFORNICAL HYPOTHALAMIC SELF-STIMULATION
CARR, KD
WOLINSKY, TD
[J]. BRAIN RESEARCH, 1993, 607 (1-2) : 141 - 148
[8] CONOVER KL, 1994, BEHAV NEUROSCI, V108, P559
[9] The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically Obese falfa rats - Reduced sensitivity compared with lean animals
Cusin, I
RohnerJeanrenaud, F
StrickerKrongrad, A
Jeanrenaud, B
[J]. DIABETES, 1996, 45 (10) : 1446 - 1451
[10] A search for the metabolic signal that sensitizes lateral hypothalamic self-stimulation in food-restricted rats
De Vaca, SC
Holiman, S
Carr, KD
[J]. PHYSIOLOGY & BEHAVIOR, 1998, 64 (03) : 251 - 260

← 1 2 3 4 →