Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution

被引：109

作者：

Tosaki, Shin-ya ^{[1
]}

Hara, Keiichi ^{[1
]}

Gnanadesikan, Vijay ^{[1
]}

Morimoto, Hiroyuki ^{[1
]}

Harada, Shinji ^{[1
]}

Sugita, Mari ^{[1
]}

Yamagiwa, Noriyuki ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

Shibasaki, Masakatsu ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 36期

关键词：

D O I：

10.1021/ja064858l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A kinetic resolution of tertiary nitroaldols derived from simple ketones is described. Mixed BINOL/biphenol La-Li heterobimetallic complexes gave the best selectivity in retro-nitroaldol reactions of racemic tertiary nitroaldols. By using a mixture of La-Li3-(1a)3 complex (LLB 2a) and La-Li3-(1b)3 (LLB* 2b) complex in a ratio of 2/1, chiral tertiary nitroaldols were obtained in 80-97% ee and 30-47% recovery yield. Copyright © 2006 American Chemical Society.

引用

页码：11776 / 11777

页数：2

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