Toll-like receptors

被引：69

作者：

Muzio, M ^{[1
]}

Mantovani, A ^{[1
]}

机构：

[1] Mario Negri Inst, Dept Immunol & Cell Biol, I-2015 Milan, Italy

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 03期

关键词：

Toll; interleukin-1; lipopolysaccharide; receptor; inflammation;

D O I：

10.1016/S1286-4579(00)00303-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) are a growing family of molecules involved in innate immunity. Accumulating evidence suggests that TLR molecules are involved in signalling receptor complexes which recognise components of Gram-positive and Gram-negative bacteria and mycobacteria. Differential expression and regulation as well as distinct though overlapping ligand recognition patterns may underlie the existence of a vast TLR family. Apparent structural and functional redundancy may render certain outputs of the TLR family robust. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：251 / 255

页数：5