The epithelial cell cytoskeleton and intracellular trafficking - III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?

被引:53
作者
Athman, R [1 ]
Louvard, D [1 ]
Robine, S [1 ]
机构
[1] Inst Curie, UMR 144, Lab Morphogenese & Signalisat Cellulaires, F-75248 Paris 5, France
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2002年 / 283卷 / 03期
关键词
F-actin; gelsolin family; cell motility; Shigella infection;
D O I
10.1152/ajpgi.00207.2002
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Villin plays a key role in the maintenance of the brush border organization by bundling F-actin into a network of parallel filaments. Our previous in vivo data on villin knockout mice showed that, although this protein is not necessary for the bundling of F-actin, it is important for the reorganization of the actin cytoskeleton elicited by stress conditions. We further investigated villin property to initiate actin remodeling in cellular processes such as hepatocyte growth factor-induced motility, morphogenesis, and bacterial infection. Our data suggest that villin is involved in actin remodeling necessary for many cellular processes requiring the actin cytoskeleton plasticity.
引用
收藏
页码:G496 / G502
页数:7
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