The epithelial cell cytoskeleton and intracellular trafficking - III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?

被引：53

作者：

Athman, R ^{[1
]}

Louvard, D ^{[1
]}

Robine, S ^{[1
]}

机构：

[1] Inst Curie, UMR 144, Lab Morphogenese & Signalisat Cellulaires, F-75248 Paris 5, France

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2002年 / 283卷 / 03期

关键词：

F-actin; gelsolin family; cell motility; Shigella infection;

D O I：

10.1152/ajpgi.00207.2002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Villin plays a key role in the maintenance of the brush border organization by bundling F-actin into a network of parallel filaments. Our previous in vivo data on villin knockout mice showed that, although this protein is not necessary for the bundling of F-actin, it is important for the reorganization of the actin cytoskeleton elicited by stress conditions. We further investigated villin property to initiate actin remodeling in cellular processes such as hepatocyte growth factor-induced motility, morphogenesis, and bacterial infection. Our data suggest that villin is involved in actin remodeling necessary for many cellular processes requiring the actin cytoskeleton plasticity.

引用

页码：G496 / G502

页数：7

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