Cytotoxic cembranoids from the soft corals Sinularia gibberosa and Sarcophyton trocheliophorum

被引：54

作者：

Duh, CY

Hou, RS

机构：

[1] Department of Marine Resources, National Sun Yat-sen University, Kaohsiung

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 06期

关键词：

D O I：

10.1021/np960174n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new cytotoxic cembranoid diterpenes, 11,12-epoxy-1(E),3(E),7(E)-cembratrien-15-ol (1), 3,4:11,12-diepoxy-15-methoxy-1(E),7(E)-cembradiene (2), 1(E),3(E),7(E),1 1(E)-cembratetraene-14,15-diol (3), and 3,14-epoxy-1(E),7(E),11(E)-cembratriene-4,15-diol (4), have been isolated from the soft coral Sinularia gibberosa. Selective cytotoxicity was also observed for the new compound, 7 beta,8 alpha-dihydroxydeepoxysarcophine (5), and for sarcophine (6), and 16-deoxysarcophine (7), isolated from the soft coral Sarcophyton trocheliophorum. The structures of the new compounds were determined by spectral and chemical methods.

引用

收藏

页码：595 / 598

页数：4

相关论文

共 18 条

[1] MODERN PULSE METHODS IN HIGH-RESOLUTION NMR-SPECTROSCOPY [J].

BENN, R ;

GUNTHER, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1983, 22 (05) :350-380

[2] SARCOPHINE, A NEW EPOXY CEMBRANOLIDE FROM MARINE ORIGIN [J].

BERNSTEIN, J ;

SHMEULI, U ;

ZADOCK, E ;

KASHMAN, Y ;

NEEMAN, I .

TETRAHEDRON, 1974, 30 (16) :2817-2824

[3] STUDIES OF AUSTRALIAN SOFT CORALS .18. FURTHER CEMBRANOID DITERPENES FROM SOFT CORALS OF THE GENUS SARCOPHYTON [J].

BOWDEN, BF ;

COLL, JC ;

MITCHELL, SJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1980, 33 (04) :879-884

[4] STUDIES OF AUSTRALIAN SOFT CORALS .10. ISOLATION OF EPOXYISONEOCEMBRENE-A FROM SINULARIA-GRAYI AND ISONEOCEMBRENE-A FROM SARCOPHYTON-EHRENBERGI [J].

BOWDEN, BF ;

COLL, JC ;

HICKS, W ;

KAZLAUSKAS, R ;

MITCHELL, SJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1978, 31 (12) :2707-2712

[5] THE STRUCTURES OF 4 ISOMERIC DIHYDROFURAN-CONTAINING CEMBRANOID DITERPENES FROM SEVERAL SPECIES OF SOFT CORAL [J].

BOWDEN, BF ;

COLL, JC ;

HEATON, A ;

KONIG, G ;

BRUCK, MA ;

CRAMER, RE ;

KLEIN, DM ;

SCHEUER, PJ .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (04) :650-659

[6] STUDIES OF AUSTRALIAN SOFT CORALS .1. NEW CEMBRENOID DITERPENE FROM A SARCOPHYTON SPECIES [J].

COLL, JC ;

HAWES, GB ;

LIYANAGE, N ;

OBERHANSLI, W ;

WELLS, RJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1977, 30 (06) :1305-1309

[7] ATTEMPTED ACID-CATALYZED TRANS-ANNULAR REACTIONS IN THE CEMBRANOIDS [J].

CZARKIE, D ;

CARMELY, S ;

GROWEISS, A ;

KASHMAN, Y .

TETRAHEDRON, 1985, 41 (06) :1049-1056

[8]

GERAN RI, 1972, CANC CHEMOTHER REP, V3, P1

[9]

GREENLAND GJ, 1994, AUST J CHEM, V77, P2013

[10] SINUGIBBEROL, A NEW CYTOTOXIC CEMBRANOID DITERPENE FROM THE SOFT CORAL SINULARIA-GIBBEROSA [J].

HOU, RS ;

DUH, CY ;

CHIANG, MY ;

LIN, CN .

JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1995, 58 (07) :1126-1130