Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

被引：2691

作者：

Polyak, Kornelia ^{[1
,2
]}

Weinberg, Robert A. ^{[3
,4
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Whitehead Inst Biomed Res, Ludwig MIT Ctr Mol Oncol, Cambridge, MA 02142 USA

[4] MIT, Dept Biol, Cambridge, MA 02142 USA

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 04期

关键词：

BREAST-CANCER CELLS; DISSEMINATED TUMOR-CELLS; E-CADHERIN; DNA METHYLATION; COLORECTAL-CANCER; EPIGENETIC INACTIVATION; DOWN-REGULATION; CARCINOMA PROGRESSION; SIGNALING PATHWAY; GENE-EXPRESSION;

D O I：

10.1038/nrc2620

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transitions between epithelial and mesenchymal states have crucial roles in embryonic development. Emerging data suggest a role for these processes in regulating cellular plasticity in normal adult tissues and in tumours, where they can generate multiple, distinct cellular subpopulations contributing to intratumoural heterogeneity. Some of these subpopulations may exhibit more differentiated features, whereas others have characteristics of stem cells. Owing to the importance of these tumour-associated phenotypes in metastasis and cancer-related mortality, targeting the products of such cellular plasticity is an attractive but challenging approach that is likely to lead to improved clinical management of cancer patients.

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页码：265 / 273

页数：9

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