Novel and alternate SNP and genetic technologies

被引:8
作者
Breen, G
机构
[1] Kings Coll London, Inst Psychiat, Div Psychol Med, Genet Sect, London SE5 8AF, England
[2] Univ Aberdeen, Sch Med, Dept Mental Hlth, Aberdeen AB9 2ZD, Scotland
关键词
melting curves; whole genome; genotyping; novel; technologies; sequencing; resequencing;
D O I
10.1097/00041444-200206000-00005
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
There are many different genotyping technologies and chemistries. Other articles in this special issue focus on nanotechnology, bioinformatics, DNA chips and genotyping methods. This article focuses on four method categories not featured elsewhere in this, or the following special issue: (1) melting curve-based technologies such as dynamic allele-specific hybridization (DASH), melting curve single nucleotide polymorphism (McSNP), fluorescent resonance energy transfer (FRET), hybridization-based melting curves, and homogeneous assay formats based on melting curves; (2) non-PCR-dependent assays such as the oligonucleotide ligation assay and Invader, and isothermal amplification techniques such as rolling circle amplification; (3) rapid whole genome sequencing with methods such as the use of single molecule arrays and molecular resonance sequencing; (4) and other promising novel technologies.
引用
收藏
页码:83 / 88
页数:6
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