Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent

被引：66

作者：

Sahota, A

Yang, M

Gao, SJ

Hui, SL

Baiyewu, O

Gureje, O

Oluwole, S

Ogunniyi, A

Hall, KS

Hendrie, HC

机构：

[1] INDIANA UNIV,SCH MED,DEPT PSYCHIAT,INDIANAPOLIS,IN 46202

[2] INDIANA UNIV,SCH MED,DEPT PSYCHIAT,INDIANAPOLIS,IN 46202

[3] INDIANA UNIV,SCH MED,DEPT MED,INDIANAPOLIS,IN 46202

[4] UNIV IBADAN,DEPT MED,IBADAN,NIGERIA

[5] UNIV IBADAN,DEPT PSYCHIAT,IBADAN,NIGERIA

[6] UNIV IBADAN,DEPT NEUROL,IBADAN,NIGERIA

来源：

ANNALS OF NEUROLOGY | 1997年 / 42卷 / 04期

关键词：

D O I：

10.1002/ana.410420418

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

As a part of our ongoing study on Alzheimer's disease (AD) in elderly African Americans, we obtained clinical assessment and apolipoprotein E (ApoE) genotype data on 288 individuals (including 60 with AD). The ApoE epsilon 4 allele frequency was significantly increased in AD patients compared with controls. The age-adjusted odds ratio (OR) for AD in epsilon 4 homozygotes was 4.83 (95% confidence interval [CI], 1.71-13.64) compared with the epsilon 3/epsilon 3 genotype, but the OR for AD with the epsilon 3/epsilon 4 genotype did not reach significance (1.20; 95% CI, 0.58-2.45). These findings suggest that the association between ApoE epsilon 4 and AD is weaker in African Americans than in whites.

引用

页码：659 / 661

页数：3

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