Medicinal Flowers. XXVII. New Flavanone and Chalcone Glycosides, Arenariumosides I II, III, and IV, and Tumor Necrosis Factor-α Inhibitors from Everlasting, Flowers of Helichrysum arenarium

被引：41

作者：

Morikawa, Toshio ^{[1
]}

Wang, Li-Bo ^{[2
,3
]}

Nakamura, Seikou ^{[2
]}

Ninomiya, Kiyofumi ^{[1
]}

Yokoyama, Eri ^{[1
]}

Matsuda, Hisashi ^{[2
]}

Muraoka, Osamu ^{[1
]}

Wu, Li-Jun ^{[3
]}

Yoshikawa, Masayuki ^{[1
,2
]}

机构：

[1] Kinki Univ, Pharmaceut Res & Technol Inst, Osaka 5778502, Japan

[2] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

[3] Shenyang Pharmaceut Univ, Fac Nat Med, Shenyang 110016, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2009年 / 57卷 / 04期

基金：

日本学术振兴会;

关键词：

Helichrysum arenarium; arenariumoside; medicinal flower; tumor necrosis factor-alpha inhibitory activity; Asteraceae; everlasting; PLANT CAMELLIA-SINENSIS; THUNBERGIANUM MIQ NAKAI; AWABUKI K-KOCH; TRITERPENE OLIGOGLYCOSIDES; PANAX-GINSENG; LIVER-INJURY; D-GALACTOSAMINE/LIPOPOLYSACCHARIDE; ZEDOARIAE RHIZOMA; BELLIS-PERENNIS; ALCOHOLIC LIVER;

D O I：

10.1248/cpb.57.361

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The methanolic extract from the flowers of Helichrysum arenarium L. MOENCH was found to show inhibitory effect on tumor necrosis factor-alpha (TNF-alpha 1 ng/ml)-induced cytotoxicity in L929 cells. From the methanolic extract, 50 constituents including four new flavanone and chalcone glycosides named arenariumosides I (1), II (2), III (3), and IV (4) were isolated. The stereostructures of 1-4 were elucidated on the basis of chemical and physicochemical evidence. Among the constituents, naringenin 7-O-beta-D-glucopyranoside (7), apigenin 7-O-beta-D-glucopyranoside (14), apigenin 7-O-gentiobioside (16), and apigenin 7,4'-di-O-beta-D-glucopyranoside (17) significantly inhibited TNF-alpha-induced cytotoxicity in L929 cells at 30 mu m.

引用

页码：361 / 367

页数：7

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