Indinavir concentrations and St John's wort

被引：630

作者：

Piscitelli, SC

Burstein, AH

Chaitt, D

Alfaro, RM

Falloon, J

机构：

[1] NIAID, Dept Pharm, NIH, Bethesda, MD 20892 USA

[2] NIAID, Warren G Magnuson Clin Ctr, NIH, Bethesda, MD 20892 USA

[3] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

来源：

LANCET | 2000年 / 355卷 / 9203期

关键词：

D O I：

10.1016/S0140-6736(99)05712-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.

引用

页码：547 / 548

页数：2

共 5 条

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