Investigation of racemisation in peptide synthesis within a micro reactor

被引：43

作者：

Watts, P

Wiles, C

Haswell, SJ

Pombo-Villar, E

机构：

[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

[2] Novartis Pharma Ltd, Nervous Syst Res, CH-4002 Basel, Switzerland

来源：

LAB ON A CHIP | 2002年 / 2卷 / 03期

关键词：

D O I：

10.1039/b203977j

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We demonstrate that peptides derived from alpha-amino acids may be prepared in a micro reactor. The peptides were prepared in 20 min with quantitative conversion, compared to batch reactions which require prolonged reaction times. We illustrate that by using dilute reagent concentrations and short reaction times, less racemisation is observed in micro reactions than in bulk reactions.

引用

收藏

页码：141 / 144

页数：4

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