Protective effect of L-carnitine in the neurotoxicity induced by the mitochondrial inhibitor 3-nitropropionic acid (3-NPA)

被引：19

作者：

Binienda, Z

Johnson, JR

Tyler-Hashemi, AA

Rountree, RL

Sapienza, PP

Ali, SF

Kim, CS

机构：

[1] US FDA, Natl Ctr Toxicol Res, Div Neurotoxicol, Jefferson, AR 72079 USA

[2] US FDA, Ctr Food Safety & Appl Nutr, Div Toxicol Res, Washington, DC 20204 USA

来源：

NEUROPROTECTIVE AGENTS: FOURTH INTERNATIONAL CONFERENCE | 1999年 / 890卷

关键词：

D O I：

10.1111/j.1749-6632.1999.tb07992.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：173 / 178

页数：6

共 14 条

[1] ACETYL-L-CARNITINE INFLUENCES THE FLUIDITY OF BRAIN MICROSOMES AND OF LIPOSOMES MADE OF RAT-BRAIN MICROSOMAL LIPID EXTRACTS [J].

ARIENTI, G ;

RAMACCI, MT ;

MACCARI, F ;

CASU, A ;

CORAZZI, L .

NEUROCHEMICAL RESEARCH, 1992, 17 (07) :671-675

[2]

BEERS RF, 1952, J BIOL CHEM, V195, P133

[3] The effects of perinatal hypoxia on the behavioral, neurochemical, and neurohistological toxicity of the metabolic inhibitor 3-nitropropionic acid [J].

Binienda, Z ;

Frederick, DL ;

Ferguson, SA ;

Rountree, RL ;

Paule, MG ;

Schmued, L ;

Ali, SF ;

Slikker, W ;

Scallet, AC .

METABOLIC BRAIN DISEASE, 1995, 10 (04) :269-282

[4] Increase in levels of total free fatty acids in rat brain regions following 3-nitropropionic acid administration [J].

Binienda, Z ;

Kim, CS .

NEUROSCIENCE LETTERS, 1997, 230 (03) :199-201

[5] Effect of acute exposure to 3-nitropropionic acid on activities of endogenous antioxidants in the rat brain [J].

Binienda, Z ;

Simmons, C ;

Hussain, S ;

Slikker, W ;

Ali, SF .

NEUROSCIENCE LETTERS, 1998, 251 (03) :173-176

[6] CARNITINE - METABOLISM AND FUNCTIONS [J].

BREMER, J .

PHYSIOLOGICAL REVIEWS, 1983, 63 (04) :1420-1480

[7]

CARROLL KK, 1976, COLUMN CHROMATOGRAPH, P173

[8]

DINNAUER M, 1991, J W SEPARATION TIMES, V5, P10

[9] L-CARNITINE INCREASES THE AFFINITY OF GLUTAMATE FOR QUISQUALATE RECEPTORS AND PREVENTS GLUTAMATE NEUROTOXICITY [J].

FELIPO, V ;

MINANA, MD ;

CABEDO, H ;

GRISOLIA, S .

NEUROCHEMICAL RESEARCH, 1994, 19 (03) :373-377

[10] NATURE AND DISTRIBUTION OF BRAIN-LESIONS IN RATS INTOXICATED WITH 3-NITROPROPIONIC ACID - A TYPE OF HYPOXIC (ENERGY DEFICIENT) BRAIN-DAMAGE [J].

HAMILTON, BF ;

GOULD, DH .

ACTA NEUROPATHOLOGICA, 1987, 72 (03) :286-297

← 1 2 →