Antioxidative properties of a newly synthesized 2-glucosaminethiazolidine-4(R)-carboxylic acid (GlcNH2CYS) in mice

被引：51

作者：

Yang Yan

Liu Wan-Shun ^{[1
]}

Han Bao-Qin

Sun Hai-Zhou

机构：

[1] Ocean Univ China, Coll Marine Life Sci, Qingdao 266003, Peoples R China

[2] Ocean Univ China, Coll Chem, Qingdao 266003, Peoples R China

来源：

NUTRITION RESEARCH | 2006年 / 26卷 / 07期

关键词：

2-glucosamine-thiazolidine-4(R)-carboxylic acid; free radical; antioxidant; acetaminophen; lipid peroxidation; oxidative stress; mice;

D O I：

10.1016/j.nutres.2006.06.014

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

A new 2-substituted thiazolidine-4(R)-carboxylic acid (TCA), 2-glucosamine-TCA (GlcNH(2)Cys), was synthesized with its antioxidative properties, compared with those of 2 other 2-substituted TCAs, 2-gluco-TCA and 2-galacto-TCA. The GlcNH(2)Cys showed antioxidative properties of scavenging reactive free radicals (hydroxyl radical and superoxide anion), preventing macromolecules damage (deoxyribose, protein, and lipid), and was hepatoprotective against acetaminophen-induced liver damage by replenishing sulfhydryl levels, increasing the total antioxidative capacity of the liver, and inhibiting lipid peroxidation. GlcNH(2)Cys is a promising compound to protect against oxidative stress xenobiotics. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：369 / 377

页数：9

共 42 条

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EFFECTS OF INDOLINIC AND QUINOLINIC AMINOXYLS ON PROTEIN AND LIPID-PEROXIDATION OF RAT-LIVER MICROSOMES [J].