Composite Outcomes Can Distort the Nature and Magnitude of Treatment Benefits in Clinical Trials

被引：12

作者：

Ferreira-Gonzalez, Ignacio ^{[1
]}

Permanyer-Miralda, Gaieta ^{[1
]}

Busse, Jason W. ^{[2
]}

Devereaux, P. J. ^{[2
]}

Guyatt, Gordon H. ^{[2
]}

Alonso-Coello, Pablo ^{[3
]}

Montori, Victor M. ^{[4
]}

机构：

[1] Hosp Gen Valle Hebron, CIBER Epidemiol & Salud Publ, Barcelona 08035, Spain

[2] McMaster Univ, Hamilton, ON L8N 3Z5, Canada

[3] Hosp Santa Creu & Sant Pau, Iberoamer Cochrane Ctr, CIBER Epidemiol & Salud Publ, Barcelona 08025, Spain

[4] Mayo Clin, Rochester, MN 55905 USA

来源：

ANNALS OF INTERNAL MEDICINE | 2009年 / 150卷 / 08期

关键词：

END-POINTS; RANDOMIZED-TRIALS;

D O I：

10.7326/0003-4819-150-8-200904210-00016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：566 / 567

页数：2

共 6 条

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Montori, V. M.
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Bryant, D. M.
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Jaeschke, R.
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[2] Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns
Ferreira-Gonzalez, Ignacio
Permanyer-Miralda, Gaieta
Busse, Jason W.
Bryant, Dianne M.
Montori, Victor M.
Alonso-Coello, Pablo
Walter, Stephen D.
Guyatt, Gordon H.
[J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 2007, 60 (07) : 651 - 657
[3] Composite outcomes in randomized trials - Greater precision but with greater uncertainty?
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[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (19): : 2554 - 2559
[4] Guyatt G, 2008, USERS GUIDES MED LIT, P237
[5] Composite Outcomes in Cardiovascular Research: A Survey of Randomized Trials
Lim, Eric
Brown, Adam
Helmy, Adel
Mussa, Shafi
Altman, Douglas G.
[J]. ANNALS OF INTERNAL MEDICINE, 2008, 149 (09) : 612 - +
[6] Validity of composite end points in clinical trials
Montori, VM
Permanyer-Miralda, G
Ferreira-González, I
Busse, JW
Pacheco-Huergo, V
Bryant, D
Alonso, J
Akl, EA
Domingo-Salvany, A
Mills, E
Wu, P
Schünemann, HJ
Jaeschke, R
Guyatt, GH
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2005, 330 (7491): : 594 - 596

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