Use of recombinant factor VIIa prior to lumbar puncture in pediatric patients with acute leukemia

被引：7

作者：

Das, Prabodh ^{[1
]}

Carcao, Manuel ^{[1
]}

Hitzler, Johann ^{[1
]}

机构：

[1] Univ Toronto, Div Hematol Oncol, Hosp Sick Children, Dept Pediat, Toronto, ON M5G 1X8, Canada

来源：

PEDIATRIC BLOOD & CANCER | 2006年 / 47卷 / 02期

关键词：

hemorrhage; lumbar; pediatric acute leukemia; prophylaxis; puncture; recombinant activated factor VII;

D O I：

10.1002/pbc.20467

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The persistence of abnormal coagulation test results after standard treatment with fresh frozen plasma (FFP) poses significant problems in children with acute leukemia requiring a diagnostic lumbar puncture and intrathecal chemotherapy. We report the prophylactic use of a single dose of 90 mu g/kg recombinant activated factor VII (rFVIIa) in three children and the rapid correction of abnormal coagulation test results previously not corrected by FFP. Administration of rFVIIa was useful in avoiding a delay of diagnostic lumbar punctures and intrathecal chemotherapy. Hemorrhagic complications and adverse effects of rFVIIa were not observed. Prospective evaluation of this indication and dose appears warranted.

引用

页码：206 / 209

页数：4

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