Induction of cytochrome P450 3A by retinoids in rat hepatocyte culture

被引：18

作者：

JurimaRomet, M

Neigh, S

Casley, WL

机构：

[1] Bureau of Drug Research, Drugs Directorate, Health Canada, Ottawa, Ontario

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1997年 / 16卷 / 04期

关键词：

cytochrome P450; retinoids; hepatocytes; rat;

D O I：

10.1177/096032719701600407

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1 Rat hepatocytes cultured on a Matrigel matrix were exposed for 48 h to all-trans-retinoic acid, 9-cis-retinoic acid, 13-cis-retinoic acid or fenretinide, 2 Cytochrome P450 3A (CYP3A) RNA levels were increased by approximately eightfold in hepatocytes treated with the retinoids compared to control cultures. 3 CYP1A1 and CYP1A2 RNA levels were only slightly affected or unaffected by the retinoids. 4 The induction of CYP3A by these therapeutically-useful retinoids suggests that they may share a common mechanism for accelerated drug catabolism and acquired clinical resistance.

引用

页码：198 / 203

页数：6

共 41 条

[1] LIAROZOLE POTENTIATES THE CANCER CHEMOPREVENTIVE ACTIVITY OF AND THE UP-REGULATION OF GAP JUNCTIONAL COMMUNICATION AND CONNEXIN43 EXPRESSION BY RETINOIC ACID AND BETA-CAROTENE IN 10T1/2 CELLS [J].