FAK and paxillin: regulators of N-cadherin adhesion and inhibitors of cell migration?

被引：84

作者：

Schaller, MD ^{[1
]}

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Lineberger Comprehens Canc Ctr, Carolina Cardiovasc Biol Ctr, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF CELL BIOLOGY | 2004年 / 166卷 / 02期

关键词：

D O I：

10.1083/jcb.200406151

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

FAK and paxillin are important components in integrin-regulated signaling. New evidence suggests that these two proteins function in crosstalk between cell-matrix and cell-cell adhesions. Further, new insight suggests that under some conditions these proteins inhibit cell migration, in contrast to their established roles in several cell systems as positive regulators of cell adhesion and migration.

引用

收藏

页码：157 / 159

页数：3

相关论文

共 14 条

[1] Regulation of cadherin function by Rho and Rac: Modulation by junction maturation and cellular context [J].

Braga, VMM ;

Del Maschio, A ;

Machesky, L ;

Dejana, E .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (01) :9-22

[2] Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes [J].

Braga, VMM ;

Betson, M ;

Li, XD ;

Lamarche-Vane, N .

MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (11) :3703-3721

[3] N-cadherin-dependent cell-cell contact regulates Rho GTPases and β-catenin localization in mouse C2C12 myoblasts [J].

Charrasse, S ;

Meriane, M ;

Comunale, F ;

Blangy, A ;

Gauthier-Rouvière, C .

JOURNAL OF CELL BIOLOGY, 2002, 158 (05) :953-965

[4] Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling [J].

Eliceiri, BP ;

Puente, XS ;

Hood, JD ;

Stupack, DG ;

Schlaepfer, DD ;

Huang, XZZ ;

Sheppard, D ;

Cheresh, DA .

JOURNAL OF CELL BIOLOGY, 2002, 157 (01) :149-159

[5] The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling [J].

Hagel, M ;

George, EL ;

Kim, A ;

Tamimi, R ;

Opitz, SL ;

Turner, CE ;

Imamoto, A ;

Thomas, SM .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (03) :901-915

[6] Differential regulation of cell motility and invasion by FAK [J].

Hsia, DA ;

Mitra, SK ;

Hauck, CR ;

Streblow, D ;

Nelson, JA ;

Ilic, D ;

Huang, S ;

Li, EG ;

Nemerow, GR ;

Leng, J ;

Spencer, KSR ;

Cheresh, DA ;

Schlaepfer, DD .

JOURNAL OF CELL BIOLOGY, 2003, 160 (05) :753-767

[7]

ILLC D, 1995, NATURE, V377, P539

[8] Integrin signalling: a new Cas(t) of characters enters the stage [J].

O'Neill, GM ;

Fashena, SJ ;

Golemis, EA .

TRENDS IN CELL BIOLOGY, 2000, 10 (03) :111-119

[9] Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase [J].

Sander, EE ;

van Delft, S ;

ten Klooster, JP ;

Reid, T ;

van der Kammen, RA ;

Michiels, F ;

Collard, JG .

JOURNAL OF CELL BIOLOGY, 1998, 143 (05) :1385-1398

[10] FAK integrates growth-factor and integrin signals to promote cell migration [J].

Sieg, DJ ;

Hauck, CR ;

Ilic, D ;

Klingbeil, CK ;

Schaefer, E ;

Damsky, CH ;

Schlaepfer, DD .

NATURE CELL BIOLOGY, 2000, 2 (05) :249-256