DAncing past the DAT at a DA synapse

被引:279
作者
Cragg, SJ
Rice, ME
机构
[1] NYU, Sch Med, Dept Physiol & Neurosci, New York, NY 10016 USA
[2] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
关键词
D O I
10.1016/j.tins.2004.03.011
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Spillover of dopamine (DA) from a release site into the extrasynaptic space is widely acknowledged. Indeed, spillover is necessary for signalling by DA because its receptors are predominantly extrasynaptic. Dopamine transporters (DATs) are often considered to participate in this process by 'gating' spillover. This article reviews the competition between DATs and diffusion in sculpting extracellular DA transients after quantal release, using a model based on data from the literature. Its conclusions challenge the view that DATs limit synaptic DA concentration and gate initial spillover from a release site; this is the work of diffusion. Rather, the greatest influence of DATs, or of their inhibition, is on the sphere of influence and lifetime of DA beyond a release site and, thus, on net extracellular concentration.
引用
收藏
页码:270 / 277
页数:8
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