The synthesis and conformational aspects of a novel dioxopiperazine -: a possible β-turn constraint

被引：3

作者：

Davies, JS

Stelmach-Diddams, M

Fromentin, R

Howells, A

Cotton, R

机构：

[1] Univ Wales, Dept Chem, Swansea SA2 8PP, W Glam, Wales

[2] Zeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 02期

关键词：

D O I：

10.1039/a904943f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic route to a novel alpha,alpha-diamino beta-keto ethoxycarbonyl-containing dioxopiperazine, capable of mimicking a beta-turn, is reported. The cis configuration of the dioxopiperazine has been rationalised by NMR spectroscopy, while computational energy calculations have been used to explain the reluctance to cyclise of N-terminal partially protected dipeptides containing alpha,alpha-amino groups.

引用

页码：239 / 243

页数：5

共 30 条

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ANTEUNIS MJO, 1978, B SOC CHIM BELG, V87, P627

[2]

Ball J B, 1990, J Mol Recognit, V3, P55, DOI 10.1002/jmr.300030202

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