Technical report: chronic and acute intracochlear infusion in rodents

被引:74
作者
Prieskorn, DM [1 ]
Miller, JM [1 ]
机构
[1] Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA
关键词
intracochlear infusion; osmotic pump; bolus injection; hearing; rodent;
D O I
10.1016/S0378-5955(99)00193-8
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
As a follow-up to the Brown ct al., 1993 technique, we have made several improvements to the micro-cannula, osmotic pump procedure, enabling chronic intracochlear infusions while maintaining hearing. In addition, acute bolus injection techniques are briefly described in guinea pig, rat and mouse. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:212 / 215
页数:4
相关论文
共 11 条
[1]   OSMOTIC PUMP IMPLANT FOR CHRONIC INFUSION OF DRUGS INTO THE INNER-EAR [J].
BROWN, JN ;
MILLER, JM ;
ALTSCHULER, RA ;
NUTTALL, AL .
HEARING RESEARCH, 1993, 70 (02) :167-172
[2]  
Carvalho GJ, 1999, AM J OTOL, V20, P87
[3]   Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3 [J].
Ernfors, P ;
Duan, ML ;
ElShamy, WM ;
Canlon, B .
NATURE MEDICINE, 1996, 2 (04) :463-467
[4]   CHRONIC DRUG INFUSION INTO THE SCALA TYMPANI OF THE GUINEA-PIG COCHLEA [J].
KINGMA, GG ;
MILLER, JM ;
MYERS, MW .
JOURNAL OF NEUROSCIENCE METHODS, 1992, 45 (1-2) :127-134
[5]  
Lalwani AK, 1996, GENE THER, V3, P588
[6]   Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss [J].
Miller, JM ;
Chi, DH ;
OKeeffe, LJ ;
Kruszka, P ;
Raphael, Y ;
Altschuler, RA .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1997, 15 (4-5) :631-643
[7]   KHRI-3 monoclonal antibody-induced damage to the inner ear: antibody staining of nascent soars [J].
Nair, TS ;
Prieskorn, DM ;
Miller, JM ;
Dolan, DF ;
Raphael, Y ;
Carey, TE .
HEARING RESEARCH, 1999, 129 (1-2) :50-60
[8]   In vivo binding and hearing loss after intracochlear infusion of KHRI-3 antibody [J].
Nair, TS ;
Prieskorn, DM ;
Miller, JM ;
Mori, A ;
Gray, J ;
Carey, TE .
HEARING RESEARCH, 1997, 107 (1-2) :93-101
[9]  
PARK GH, 1998, 21 MIDW M ARO ST PET
[10]  
SCHINDLER RA, 1995, AM J OTOL, V16, P304