Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans

被引：110

作者：

O'Brien, Kara L. ^{[1
]}

Liu, Jinyan ^{[1
]}

King, Sharon L. ^{[1
]}

Sun, Ying-Hua ^{[1
]}

Schmitz, Joern E. ^{[2
]}

Lifton, Michelle A. ^{[2
]}

Hutnick, Natalie A. ^{[3
]}

Betts, Michael R. ^{[3
]}

Dubey, Sheri A. ^{[4
]}

Goudsmit, Jaap ^{[5
]}

Shiver, John W. ^{[4
]}

Robertson, Michael N. ^{[4
]}

Casimiro, Danilo R. ^{[4
]}

Barouch, Dan H. ^{[1
,6
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA 02215 USA

[3] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

[4] Merck Res Labs, West Point, PA USA

[5] Crucell Holland BV, Leiden, Netherlands

[6] MIT, Ragon Inst Massachusetts Gen Hosp, Cambridge, MA USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 08期

基金：

美国国家卫生研究院; 比尔及梅琳达.盖茨基金会;

关键词：

RHESUS-MONKEYS; IMMUNOGENICITY; REPLICATION; VECTORS; SAFETY; STEP;

D O I：

10.1038/nm.1991

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The immunologic basis for the potential enhanced HIV-1 acquisition in adenovirus serotype 5 (Ad5)-seropositive individuals who received the Merck recombinant Ad5 HIV-1 vaccine in the STEP study remains unclear. Here we show that baseline Ad5-specific neutralizing antibodies are not correlated with Ad5-specific T lymphocyte responses and that Ad5-seropositive subjects do not develop higher vector-specific cellular immune responses as compared with Ad5-seronegative subjects after vaccination. These findings challenge the hypothesis that activated Ad5-specific T lymphocytes were the cause of the potential enhanced HIV-1 susceptibility in the STEP study. (C) 2009 Nature America, Inc. All rights reserved.

引用

页码：873 / 875

页数：3

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