Biochemical mechanisms of gene regulation by polycomb group protein complexes

被引：211

作者：

Mueller, Juerg ^{[1
]}

Verrijzer, Peter ^{[2
,3
]}

机构：

[1] EMBL, Gene Express Programme, D-69117 Heidelberg, Germany

[2] Erasmus MC, NL-3015 GE Rotterdam, Netherlands

[3] Ctr Biomed Genet, Dept Biochem, NL-3015 GE Rotterdam, Netherlands

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 02期

关键词：

HISTONE METHYLTRANSFERASE ACTIVITY; METHYL-LYSINE-BINDING; STRUCTURAL BASIS; DEVELOPMENTAL REGULATORS; DISTINCT ROLES; SEX-COMB; DROSOPHILA; CHROMATIN; TRITHORAX; GENOME;

D O I：

10.1016/j.gde.2009.03.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polycomb group (PcG) proteins are transcriptional repressors that control expression of developmental regulator genes in animals and plants. Recent advances in our understanding of the PcG system include biochemical purifications that revealed a substantial variety in PcG complex composition. These different complexes contain distinct chromatin-modifying activities and engage in cross-talk with other chromatin modifications. Complementing these biochemical analyses, structural studies have begun to provide insight into how PcG proteins interact with each other and with chromatin. Finally, genome-wide binding profiling and the ensuing functional analysis of target gene regulation revealed that the PcG system is not only used for the permanent silencing of developmental regulator genes. Rather, PcG mediated repression also constitutes a mechanism for dynamic control of gene transcription.

引用

页码：150 / 158

页数：9

共 80 条

[1] Comparing active and repressed expression states of genes controlled by the Polycomb/Trithorax group proteins [J].

Beisel, Christian ;

Buness, Andreas ;

Roustan-Espinosa, Ian M. ;

Koch, Britta ;

Schmitt, Sabine ;

Haas, Stefan A. ;

Hild, Marc ;

Katsuyama, Tomonori ;

Paro, Renato .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (42) :16615-16620

[2] Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila [J].

Bell, Oliver ;

Wirbelauer, Christiane ;

Hild, Marc ;

Scharf, Annette N. D. ;

Schwaiger, Michaela ;

MacAlpine, David M. ;

Zilbermann, Frederic ;

van Leeuwen, Fred ;

Bell, Stephen P. ;

Imhof, Axel ;

Garza, Dan ;

Peters, Antoine H. F. M. ;

Schuebeler, Dirk .

EMBO JOURNAL, 2007, 26 (24) :4974-4984

[3] The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity [J].

Ben-Saadon, Ronen ;

Zaaroor, Daphna ;

Ziv, Tamar ;

Ciechanover, Aaron .

MOLECULAR CELL, 2006, 24 (05) :701-711

[4] The complex language of chromatin regulation during transcription [J].

Berger, Shelley L. .

NATURE, 2007, 447 (7143) :407-412

[5] Covalent modifications of histones during development and disease pathogenesis [J].

Bhaumik, Sukesh R. ;

Smith, Edwin ;

Shilatifard, Ali .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (11) :1008-1016

[6]

Birve A, 2001, DEVELOPMENT, V128, P3371

[7] Polycomb complexes repress developmental regulators in murine embryonic stem cells [J].

Boyer, LA ;

Plath, K ;

Zeitlinger, J ;

Brambrink, T ;

Medeiros, LA ;

Lee, TI ;

Levine, SS ;

Wernig, M ;

Tajonar, A ;

Ray, MK ;

Bell, GW ;

Otte, AP ;

Vidal, M ;

Gifford, DK ;

Young, RA ;

Jaenisch, R .

NATURE, 2006, 441 (7091) :349-353

[8] Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions [J].

Bracken, AP ;

Dietrich, N ;

Pasini, D ;

Hansen, KH ;

Helin, K .

GENES & DEVELOPMENT, 2006, 20 (09) :1123-1136

[9] Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b [J].

Buchwald, Gretel ;

van der Stoop, Petra ;

Weichenrieder, Oliver ;

Perrakis, Anastassis ;

van Lohuizen, Maarten ;

Sixma, Titia K. .

EMBO JOURNAL, 2006, 25 (11) :2465-2474

[10] Role of histone H3 lysine 27 methylation in polycomb-group silencing [J].

Cao, R ;

Wang, LJ ;

Wang, HB ;

Xia, L ;

Erdjument-Bromage, H ;

Tempst, P ;

Jones, RS ;

Zhang, Y .

SCIENCE, 2002, 298 (5595) :1039-1043

← 1 2 3 4 5 6 7 8 →