Glucocorticoid receptor isoforms generatetranscription specificity

被引：187

作者：

Lu, Nick Z. ^{[1
]}

Cidlowski, John A. ^{[1
]}

机构：

[1] NIEHS, Mol Endocrinol Grp, Lab Signal Transduct, Mol Endocrinol Grp,NIH,Dept Hlth & Human Serv, Res Triangle Pk, NC 27709 USA

来源：

TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.tcb.2006.04.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glucocorticoids are necessary for life and are essential in all aspects of health and disease as they regulate processes from mitosis to apoptosis, from metabolism to growth and development. However, responses to glucocorticoids vary among individuals, cells and tissues. Recent evidence indicates that multiple glucocorticoid receptor (GR) isoforms are generated from one single GR gene by alternative splicing and alternative translation initiation. These isoforms all have unique tissue distribution patterns and transcriptional regulatory profiles. Furthermore, each is subject to various post-translational modifications that affect receptor function. Thus, increasing evidence suggests that unique GR isoform compositions within cells could determine the cell-specific response to glucocorticoids. Here, we discuss a new molecular model potentially underlying tissue-specific glucocorticoid resistance and selectivity.

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收藏

页码：301 / 307

页数：7

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