A humanized antibody against human cytomegalovirus (CMV) gpUL75 (gH) for prophylaxis or treatment of CMV infections

被引：12

作者：

Hamilton, AA

Manuel, DM

Grundy, JE

Turner, AJ

King, SI

Adair, JR

White, P

Carr, FJ

Harris, WJ

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT CLIN IMMUNOL,LONDON NW3 2PF,ENGLAND

[2] SCOTGEN BIOPHARMACEUT INC,ABERDEEN,SCOTLAND

[3] UNIV ABERDEEN,INST MED SCI,DEPT MOL & CELL BIOL,ABERDEEN,SCOTLAND

来源：

JOURNAL OF INFECTIOUS DISEASES | 1997年 / 176卷 / 01期

关键词：

D O I：

10.1086/514040

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A humanized monoclonal antibody that binds to the 86-kDa glycoprotein, gpUL75 (gH), of human cytomegalovirus (CMV) has been developed, The six complementarity determining regions of the heavy and light chains of the mouse antibody HCMV16 were transferred to human antibody framework sequences and combined with human antibody constant regions to produce a complete antibody. The reshaped antibody recognized cells infected with a variety of virus strains and neutralized clinical isolates of CMV as efficiently as laboratory strains in a conventional plaque reduction assay, This antibody provides a potential agent for the prevention or treatment of CMV infections in humans.

引用

收藏

页码：59 / 68

页数：10

相关论文

共 76 条

[1] HUMAN MONOCLONAL-ANTIBODIES NEUTRALIZING CYTOMEGALOVIRUS (CMV) FOR PROPHYLAXIS OF CMV DISEASE - REPORT OF A PHASE-I TRIAL IN BONE-MARROW TRANSPLANT RECIPIENTS [J].

AULITZKY, WE ;

SCHULZ, TF ;

TILG, H ;

NIEDERWIESER, D ;

LARCHER, K ;

OSTBERG, L ;

SCRIBA, M ;

MARTINDALE, J ;

STERN, AC ;

GRASS, P ;

MACH, M ;

DIERICH, P ;

HUBER, C .

JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (06) :1344-1347

[2] PHASE-I STUDY ON HUMAN MONOCLONAL-ANTIBODY AGAINST CYTOMEGALOVIRUS - PHARMACOKINETICS AND IMMUNOGENICITY [J].

AZUMA, J ;

KURIMOTO, T ;

TSUJI, S ;

MOCHIZUKI, N ;

FUJINAGA, S ;

MATSUMOTO, Y ;

MASUHO, Y .

JOURNAL OF IMMUNOTHERAPY, 1991, 10 (04) :278-285

[3] DOWN-REGULATION OF THE CLASS-I HLA HETERODIMER AND BETA-2-MICROGLOBULIN ON THE SURFACE OF CELLS INFECTED WITH CYTOMEGALOVIRUS [J].

BARNES, PD ;

GRUNDY, JE .

JOURNAL OF GENERAL VIROLOGY, 1992, 73 :2395-2403

[4]

BEBBINGTON C R, 1991, Methods (Orlando), V2, P136, DOI 10.1016/S1046-2023(05)80214-2

[5] HIGH-LEVEL EXPRESSION OF A RECOMBINANT ANTIBODY FROM MYELOMA CELLS USING A GLUTAMINE-SYNTHETASE GENE AS AN AMPLIFIABLE SELECTABLE MARKER [J].

BEBBINGTON, CR ;

RENNER, G ;

THOMSON, S ;

KING, D ;

ABRAMS, D ;

YARRANTON, GT .

BIO-TECHNOLOGY, 1992, 10 (02) :169-175

[6] VIRUS-SPECIFIC ANTIBODY-RESPONSES TO HUMAN CYTOMEGALOVIRUS (HCMV) IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED PERSONS WITH HCMV RETINITIS [J].

BOPPANA, SB ;

POLIS, MA ;

KRAMER, AA ;

BRITT, WJ ;

KOENIG, S .

JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (01) :182-185

[7] CELL-SURFACE EXPRESSION OF HUMAN CYTOMEGALOVIRUS (HCMV) GP55-116 (GB) - USE OF HCMV-RECOMBINANT VACCINIA VIRUS-INFECTED CELLS IN ANALYSIS OF THE HUMAN NEUTRALIZING ANTIBODY-RESPONSE [J].

BRITT, WJ ;

VUGLER, L ;

BUTFILOSKI, EJ ;

STEPHENS, EB .

JOURNAL OF VIROLOGY, 1990, 64 (03) :1079-1085

[8] NEUTRALIZING ANTIBODIES DETECT A DISULFIDE-LINKED GLYCOPROTEIN COMPLEX WITHIN THE ENVELOPE OF HUMAN CYTOMEGALOVIRUS [J].

BRITT, WJ .

VIROLOGY, 1984, 135 (02) :369-378

[9] COMPARISON OF THE EFFECTOR FUNCTIONS OF HUMAN-IMMUNOGLOBULINS USING A MATCHED SET OF CHIMERIC ANTIBODIES [J].

BRUGGEMANN, M ;

WILLIAMS, GT ;

BINDON, CI ;

CLARK, MR ;

WALKER, MR ;

JEFFERIS, R ;

WALDMANN, H ;

NEUBERGER, MS .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (05) :1351-1361

[10]

CHEE MS, 1990, CURR TOP MICROBIOL I, V154, P126

← 1 2 3 4 5 6 7 8 →