Increased frontal cortical folding in autism: a preliminary MRI study

被引：137

作者：

Hardan, AY ^{[1
]}

Jou, RJ ^{[1
]}

Keshavan, MS ^{[1
]}

Varma, R ^{[1
]}

Minshew, NJ ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2004年 / 131卷 / 03期

关键词：

gyrification index; magnetic resonance imaging; prefrontal cortex; cerebral convolution; autistic disorder;

D O I：

10.1016/j.pscychresns.2004.06.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The gyrification index (GI), the ratio of total to outer cortical contour, was applied to measure the cerebral folding patterns in autism. GI was examined on a frontal coronal slice obtained from MRI scans of 30 nonmentally retarded individuals with autism and 32 matched healthy controls. In the autistic group, left frontal GI was higher in children and adolescents but not in adults. Cortical folding was decreased bilaterally with age in the total autistic sample but not in controls. These preliminary finding; suggest that the gyrification patterns in autism may be abnormal, which could be related to the various cortical anomalies observed in this disorder. (C) 2001 Elsevier Ireland Ltd. All rights reserved.

引用

页码：263 / 268

页数：6

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