Cytokines and costimulatory molecules as genetic adjuvants

被引：81

作者：

Pasquini, S ^{[1
]}

Xiang, Z ^{[1
]}

Wang, Y ^{[1
]}

He, Z ^{[1
]}

Deng, H ^{[1
]}

BlaszczykThurin, M ^{[1
]}

Ertl, HCJ ^{[1
]}

机构：

[1] WISTAR INST ANAT & BIOL, PHILADELPHIA, PA 19104 USA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 1997年 / 75卷 / 04期

关键词：

adjuvants; costimulatory molecules; cytokines; genetic vaccines;

D O I：

10.1038/icb.1997.62

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA vectors expressing an antigen derived from a pathogen or a cancerous cell have been shown, after inoculation into experimental animals, to trigger de novo synthesis of foreign proteins, which induce an immune response. This immune response can be modulated by coinoculation of vectors encoding either cytokines or costimulatory molecules. A variety of cytokines such as granulocyte/macrophage colony-stimulating factor (GM-CSF), IL-2, IL-4, IL-12 and IFN-gamma, as well as the costimulatory molecule B7.1, have been tested to date for their ability to amplify the immune response to genetic vaccines. Although the results obtained thus far clearly show that coadministration of vectors expressing immunomodulatory molecules, such as cytokines, may increase the efficacy of genetic vaccines, this approach is currently considered unsuitable for use in human patients due to the potential side effects of persistent cytokine expression.

引用

页码：397 / 401

页数：5

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