Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment induced by N-methyl-D-aspartate receptor antagonist in mice

被引：85

作者：

Han, Ren-Wen ^{[1
,2
,3
]}

Yin, Xin-Qiang ^{[1
,2
,3
]}

Chang, Min ^{[1
,2
,3
]}

Peng, Ya-Li ^{[1
,2
,3
]}

Li, Wei ^{[1
,2
,3
]}

Wang, Rui ^{[1
,2
,3
,4
]}

机构：

[1] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Sch Life Sci, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China

[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[4] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chinese Med & Mol Pharmacol, Hong Kong, Hong Kong, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2009年 / 455卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Neuropeptide S (NPS); N-Methyl-D-aspartate (NMDA) receptor; Learning and memory; Morris water maze; RAT-BRAIN; SYSTEM EXPRESSION; FOOD-INTAKE; WATER-MAZE; HIPPOCAMPUS; NEURONS; IDENTIFICATION; HYPOTHALAMUS; ACTIVATION; RESPONSES;

D O I：

10.1016/j.neulet.2009.03.023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Neuropeptide S (NPS) is a recently discovered peptide shown to be involved in regulating arousal and anxiety. NPS receptor (NPSR) mRNA is expressed significantly in the major input and output regions of hippocampal formation, which are critical in the modulation of learning and memory. However, the role of NPS/NPSR system in regulating of learning and memory is still unknown. Here, we use the Morris water maze (MWM) to determine the effects of NPS on spatial learning and memory following intracerebroventricular (i.c.v.) injection in mice. Our data show that i.c.v. injection of NPS facilitates spatial memory in the MWM without significant alteration of latency to the target and swimming speed. Furthermore, NPS (i.c.v.) mitigates spatial memory impairment induced by the selective N-methyl-D-aspartate receptor antagonist MK801. Taken together, our results firstly demonstrate that NPS facilitates spatial memory and mitigates MK801-induced spatial memory impairment in mice. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：74 / 77

页数：4

共 31 条

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